Korean J Pain.  2015 Apr;28(2):153-155. 10.3344/kjp.2015.28.2.153.

Delayed Allergic Reaction to Secondary Administrated Epidural Hyaluronidase

• Park AR
• Kim WM
• Heo BH

• KMID: 2278281
• DOI: http://doi.org/10.3344/kjp.2015.28.2.153

Abstract

We are reporting a rare case of a delayed hypersensitivity reaction caused by hyaluronidase allergy following a lumbar transforaminal epidural block. Using an intradermal skin test, we have provided evidence that the systemic allergic reaction resulted from hypersensitivity to hyaluronidase. To our knowledge, this is a rare case of a delayed hypersensitivity reaction to epidural hyaluronidase, comprised of an initial exposure to hyaluronidase with no subsequent allergic response in prior block followed by a subsequent delayed reaction to hyaluronidase during a second epidural block.

Keyword

Allergy; Epidural; Hyaluronidase; Hypersensitivity; Pain; Skin test

MeSH Terms

Hyaluronoglucosaminidase*
Hypersensitivity*
Hypersensitivity, Delayed
Skin Tests
Hyaluronoglucosaminidase