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Randomized, Double-Blind, Placebo-Controlled Trial on the Efficacy of Hyaluronidase in Preventing Perineal Trauma in Nulliparous Women

Kwon H, Park HS, Shim JY, Lee KW, Choi SJ, Choi GY

PURPOSE: Hyaluronidase (HAase) has many uses in medicine, and reports suggest that it affects perineal tissue during fetal passage through the vaginal canal. However, its potential use for preventing perineal...
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Treatment of post-traumatic hematoma and fibrosis using hyaluronidase injection

Han JH, Kim J, Yoon KC, Shin HW

Patients complaining of swelling and hematoma caused by contusion of the face can be easily seen in the emergency room. Most of the treatments were conservative treatments such as ice...
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Complex Regional Pain Syndrome of the Upper Limbs Caused by Facial Pain

Noh KM, Park KB

Polyacrylamide hydrogel is a widely used filler material in cosmetic procedures performed on the face and breasts. Recently, however, complications including inflammation, deformity, and pain have been reported. The present...
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Antioxidant and Antiaging Assays of Hibiscus sabdariffa Extract and Its Compounds

Widowati W, Rani AP, Hamzah RA, Arumwardana S, Afifah E, Kusuma HS, Rihibiha D, Nufus H, Amalia A

Skin aging is a complex biological process due to intrinsic and extrinsic factors. Free radical oxidative is one of extrinsic factors that induce activation of collagenase, elastase and hyaluronidase. Natural...
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Efficacy and Safety of Sodium Hyaluronate with 1,4-Butanediol Diglycidyl Ether Compared to Sodium Carboxymethylcellulose in Preventing Adhesion Formation after Lumbar Discectomy

Ji GY, Oh CH, Moon BG, Yi S, Han IB, Heo DH, Kim KT, Shin DA, Kim KN

OBJECTIVE: Epidural injection of hyaluronic acid may prevent adhesion formation after spine surgery, but the compounds used to stabilize hyaluronidase could interfere with its anti-adhesion effects. The present study was...
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Delayed Allergic Reaction to Secondary Administrated Epidural Hyaluronidase

Park AR, Kim WM, Heo BH

We are reporting a rare case of a delayed hypersensitivity reaction caused by hyaluronidase allergy following a lumbar transforaminal epidural block. Using an intradermal skin test, we have provided evidence...
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An Evaluation of the Effectiveness of Hyaluronidase in the Selective Nerve Root Block of Radiculopathy: A Double Blind, Controlled Clinical Trial

Ko SB, Vaccaro AR, Chang HJ, Shin DY

STUDY DESIGN: Prospective, double-blind, randomized controlled trial. PURPOSE: To determine the ability of hyaluronidase to provide longer lasting pain relief and functional improvement in patients with lumbar radiculopathy. OVERVIEW OF LITERATURE: Selective...
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Expression of Hyaluronidase-4 in a Rat Spinal Cord Hemisection Model

Tachi Y, Okuda T, Kawahara N, Kato N, Ishigaki Y, Matsumoto

STUDY DESIGN: Examination of hyaluronidase-4 (Hyal-4) expression in a rat spinal cord hemisection model. PURPOSE: To determine the status of Hyal-4 expression after hemisection of the spinal cord, and the relationship...
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Cerebral Angiographic Findings of Cosmetic Facial Filler-related Ophthalmic and Retinal Artery Occlusion

Kim YK, Jung C, Woo SJ, Park KH

Cosmetic facial filler-related ophthalmic artery occlusion is rare but is a devastating complication, while the exact pathophysiology is still elusive. Cerebral angiography provides more detailed information on blood flow of...
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Treatment of Lower Eyelid Swelling after Retrobulbar Hyaluronic Acid Filler Injection in Phthisis Bulbi

Jung SI, Kwon JW, Jung JH

PURPOSE: To report treatment with hyaluronidase of lower lid swelling lasting for 1 year after retrobulbar hyaluronic acid filler injection due to phthisis bulbi. CASE SUMMARY: A 54-year-old female presented with...
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Comment on the Evaluation of the Effectiveness of Hyaluronidase in the Selective Nerve Root Block of Radiculopathy

Manchikanti L, Kaye AD

No abstract available.
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Acute allergic reaction caused by hyaluronidase used in the pain management: a case report and literature review: A case report

Song YK, Kim YD, Kim JH

  • KMID: 1908524
  • Anesth Pain Med.
  • 2014 Jul;9(3):174-178.
Hyaluronidase is a protein enzyme extracted from goat or ovine testis. It breaks down hyaluronic acid in connective tissues, thereby reducing swelling and edema and increasing drug penetration into tissues...
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Investigation of the Degradation-Retarding Effect Caused by the Low Swelling Capacity of a Novel Hyaluronic Acid Filler Developed by Solid-Phase Crosslinking Technology

Park S, Park KY, Yeo IK, Cho SY, Ah YC, Koh HJ, Park WS, Kim BJ

  • KMID: 2368157
  • Ann Dermatol.
  • 2014 Jun;26(3):357-362.
BACKGROUND: A variety of hyaluronic acid (HA) fillers demonstrate unique physical characteristics, which affect the quality of the HA filler products. The critical factors that affect the degradation of HA...
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Formulation Characteristics of Three Kinds of Elravie(R) Fillers

Song YS, Lee Y, Kim HM, Son IP, Chung BY, Lee JO, Lim CY, Park KY, Li K, Kim BJ

  • KMID: 2246403
  • Korean J Dermatol.
  • 2014 Feb;52(2):100-105.
BACKGROUND: Hyaluronic acid (HA) is a mucopolysaccharide that occurs naturally throughout the human body, where it attaches to collagen and elastin to form cartilage, and also helps maintain the strength...
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Epidural Lysis of Adhesions

Lee F, Jamison DE, Hurley RW, Cohen SP

As our population ages and the rate of spine surgery continues to rise, the use epidural lysis of adhesions (LOA) has emerged as a popular treatment to treat spinal stenosis...
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Clinical Outcomes of Epidural Neuroplasty for Cervical Disc Herniation

Park EJ, Park SY, Lee SJ, Kim NS, Koh DY

Cervical disc herniation is a common disorder characterized by neck pain radiating to the arm and fingers as determined by the affected dermatome. This condition has a favorable prognosis, but...
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Effects of Subacromial Bursa Injection With Corticosteroid and Hyaluronidase According to Dosage

Choi WD, Cho DH, Hong YH, Noh JH, Lee ZI, Byun SD

OBJECTIVE: To evaluate effects of subacromial bursa injection with steroid according to dosage and to investigate whether hyaluronidase can reduce steroid dosage. METHODS: Thirty patients with periarticular shoulder disorder were assigned...
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The Effect of Hyaluronidase in Interlaminar Lumbar Epidural Injection for Failed Back Surgery Syndrome

Kim SB, Lee KW, Lee JH, Kim MA, An BW

OBJECTIVE: To evaluate the effect of hyaluronidase in patients with failed back surgery syndrome (FBSS) treated with interlaminar lumbar epidural injection (ILEI). METHOD: Sixty patients suffering from severe low back pain...
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The Additive Effects of Hyaluronidase in Subacromial Bursa Injections Administered to Patients with Peri-Articular Shoulder Disorder

Byun SD, Park DH, Hong YH, Lee ZI

OBJECTIVE: To evaluate the additive effects of hyaluronidase combined with steroids in patients with peri-articular shoulder disorder. METHOD: Thirty patients with peri-articular shoulder disorder were given subacromial bursa injections once a...
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The Additional Effect of Hyaluronidase in Lumbar Interlaminar Epidural Injection

Kim SB, Lee KW, Lee JH, Kim MA, Kim BH

OBJECTIVE: To evaluate the effect of hyaluronidase in lumbar interlaminar epidural injection (LIEI) for low back pain and sciatica. METHOD: Sixty-one patients suffering from severe low back pain and sciatica were...
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