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Delayed Allergic Reaction to Secondary Administrated Epidural Hyaluronidase

Park AR, Kim WM, Heo BH

We are reporting a rare case of a delayed hypersensitivity reaction caused by hyaluronidase allergy following a lumbar transforaminal epidural block. Using an intradermal skin test, we have provided evidence...
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Incidence of newly developed postoperative low back pain with median versus paramedian approach for spinal anesthesia

Lee JH, Yoon DH, Heo BH

Background The effects of anesthetic techniques on postdural puncture backache (PDPB) have not been specifically evaluated. The purpose of this study was to compare the incidence and severity of PDPB between...
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A New Rat Model of Cisplatin-induced Neuropathic Pain

Lin H, Heo BH, Yoon MH

BACKGROUND: Chemotherapy-induced peripheral neuropathy is a major side effect of anti-cancer drugs, and our knowledge of its mechanisms is lacking. Several models for chemotherapy-induced neuropathy have been introduced. However, the...
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A Comparative Efficacy of Propacetamol and Ketorolac in Postoperative Patient Controlled Analgesia

Heo BH, Park JH, Choi JI, Kim WM, Lee HG, Cho SY, Yoon MH

BACKGROUND: Ketorolac has been used as a postoperative analgesia in combination with opioids. However, the use of ketorolac may produce serious side effects in vulnerable patients. Propacetamol is known to...
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The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Intrathecal Zaprinast in the Formalin Test of Rats

Yoon SJ, Kim YO, Huang LJ, Cui JH, Heo BH, Jeong ST, Yoon MH

BACKGROUND: Spinal zaprinast, phospodiesterase inhibitor, has been shown to have an antinociception through an increase of cGMP. The aim of this study was to examine the role of spinal adrenergic...
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Spinal Noradrenergic Modulation and the Role of the Alpha-2 Receptor in the Antinociceptive Effect of Intrathecal Nefopam in the Formalin Test

Jeong SH, Heo BH, Park SH, Kim WM, Lee HG, Yoon MH, Choi JI

BACKGROUND: Nefopam has shown an analgesic effect on acute pain including postoperative pain. The reuptake of monoamines including serotonin and noradrenaline has been proposed as the mechanism of the analgesic...
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Effect-site concentration of remifentanil for blunting hemodynamic response to double lumen endobronchial intubation during target controlled infusion-total intravenous anesthesia using propofol with remifentanil

Heo BH, Yoon MH, Lee HG, Kim WM

BACKGROUND: This study was undertaken to determine the effect-site concentration of remifentanil for blunting hemodynamic responses to double lumen endobronchial intubation during target controlled infusion (TCI)-total intravenous anesthesia (TIVA) using...
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Epidural Infusion of Morphine and Levobupivacaine through a Subcutaneous Port for Cancer Pain Management

Heo BH, Pyeon TH, Lee HG, Kim WM, Choi JI, Yoon MH

BACKGROUND: To manage intractable cancer pain, an alternative to systemic analgesics is neuraxial analgesia. In long-term treatment, intrathecal administration could provide a more satisfactory pain relief with lower doses of...
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The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain

Kim DY, Chae JW, Lim CH, Heo BH, Park KS, Lee HG, Choi JI, Yoon MH, Kim WM

BACKGROUND: Nefopam has been known as an inhibitor of the reuptake of monoamines, and the noradrenergic and/or serotonergic system has been focused on as a mechanism of its analgesic action....
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Comparison of effects of intraoperative nefopam and ketamine infusion on managing postoperative pain after laparoscopic cholecystectomy administered remifentanil

Choi SK, Yoon MH, Choi JI, Kim WM, Heo BH, Park KS, Song JA

BACKGROUND: Although intraoperative opioids provide more comfortable anesthesia and reduce the use of postoperative analgesics, it may cause opioid induced hyperalgesia (OIH). OIH is an increased pain response to opioids...
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