Korean J Pediatr Hematol Oncol.  2001 Apr;8(1):9-16.

Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Children with Acute Myelogenous Leukemia in Korea

• Shin EY

Abstract

PURPOSE
Autografts with peripheral blood stem cells (PBSCT) have become an accepted alternative to bone marrow transplantation for restoring hematopoiesis after marrow ablative therapy.
METHODS
Questionnaires are given to all the transplantation centers in Korea. Eleven centers reported 63 cases and retrospective analysis of these cases were done.
RESULTS
Sixty-three children with acute myelogenous leukemia (AML) underwent PBSCT following cytoreductive chemotherapy at 11 transplant centers of the Korean Society of Pediatric Hematology-Oncology from January, 1996 through June, 2000. The patients consisted of 40 males and 23 females with a median age at PBSCT of 10 year (range 1~16). Peripheral blood stem cell (PBSC) were collected by a median of 5 apheresis per patient. Various kinds of multi-drug therapy as cytoreductive regimen were used, and the 'BCVAC' regimen consisting of BCNU, cyclophosphamide, VP-16 and cytarabine was used in 35 patients. The median number of infused mononuclear cell (MNC) and CD34 cells was 8.14 (0.3~26.6) 108/kg and 4.90 (0.12~46.9) 106/kg, respectively. Hematological recovery was evaluated in all patients. The median number of days required to achieve an absolute neutrophil count (ANC) of > 500/mm3, > 1,000/mm3 and platelet count of > 50 103/mm3 was 12 (8~48), 12 (9~84) and 35 (10~370), respectively. Sixteen patients relapsed 1 month to 18 months (median 2 months) after PBSCT, 1 patient progressed to secondary MDS 15 months after PBSCT and 1 patient died at d+39 due to CMV infection. So currently 45 patients are surviving disease free at 2 to 50 months (median 23 months).
CONCLUSION
Even though the follow-up period was short and the number of patient was small the autologous PBSCT might be an alternative therapy in childhood AML.

Keyword

Peripheral blood stem cell transplantaion; Children; Acute myelogenous leukemia; Korea

MeSH Terms

Autografts
Blood Component Removal
Bone Marrow
Bone Marrow Transplantation
Carmustine
Child
Cyclophosphamide
Cytarabine
Drug Therapy
Etoposide
Female
Follow-Up Studies
Hematopoiesis
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Humans
Korea*
Leukemia, Myeloid, Acute*
Male
Neutrophils
Platelet Count
Surveys and Questionnaires
Retrospective Studies
Stem Cells
Carmustine
Cyclophosphamide
Cytarabine
Etoposide