Korean J Pathol.  2010 Apr;44(2):220-224.

Fine Needle Aspiration Biopsy of a Myxoid Leiomyosarcoma with Epithelioid Features and It Metastasized to the Abdominal Wall: A Case Report

• Maeng LS
• Chae HS
• Lee A
• Chung Y
• Lee KY

Abstract

We present the cytologic findings observed in a fine needle aspiration biopsy specimen of a rare myxoid variant of leiomyosarcoma with epithelioid features and the tumor had metastasized to the abdominal wall. The aspirate showed hypercellularity in a hemorrhagic background. Some large 3-dimensional aggregates of spindle cells were observed. Each cell had a solitary ovoid-to-elongated nucleus with finely granulated chromatin, one or two small distinct nucleoli and an irregular nuclear membrane. There were irregular fascicles of spindle cells with cigar-shaped, blunt-ended nuclei admixed with inflammatory cells. Epithelioid cells with a rather narrow, dense cytoplasmic rim and a well-defined cell border were embedded in a myxoid matrix in a cord-like and cluster arrangement. The matrix appeared as a pale green substance with sharply defined edges. There were very few mitoses. These cytologic features were the same as those of a uterine myxoid leiomyosarcoma that was surgically excised 7 years ago, and immunohistochemical staining revealed the smooth muscle origin of the tumor.

Keyword

Cytology; Biopsy, fine-needle; Uterus; Leiomyosarcoma; Neoplasm metastasis

MeSH Terms

Abdominal Wall
Biopsy
Biopsy, Fine-Needle
Chromatin
Cytoplasm
Epithelioid Cells
Leiomyosarcoma
Mitosis
Muscle, Smooth
Neoplasm Metastasis
Nuclear Envelope
Uterus
Chromatin