Korean J Pathol.
2010 Aug;44(4):360-369.
Prognostic Significance of Glycolytic Metabolic Change Related to HIF-1alpha in Oral Squamous Cell Carcinomas
- Affiliations
-
- 1Division of Medical Oncology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 2Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. ssuki76@catholic.ac.kr
- 3Department of Radiation Oncology, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 4Department of Otorhinolaryngology, The Catholic University of Korea College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND
Growing tumors adapt to a hypoxic environment and increase anaerobic glycolysis. This metabolic switch is related to aggressive behavior. We investigated the relationship between glycolytic metabolism biomarkers associated with hypoxia-inducible factor (HIF)-1alpha and prognosis.
METHODS
We performed immunohistochemical staining of HIF-1alpha, pyruvate dehydrogenase kinase (PDK) 1 and lactate dehydrogenase (LDH) 5 in 74 patients with oral squamous cell carcinoma (SCC) who had received curative radical resection.
RESULTS
High reactivity of HIF-1alpha, PDK 1 and LDH 5 was observed in 29 (39.2%), 32 (43.2%) and 54 (73.0%) patients, respectively. Expression levels of the three biomarkers were significantly correlated. All three markers were highly expressed in 16 (21.6%) patients. Elevated expression of the three markers was associated with increased invasiveness (p = 0.043) and recurrence (p = 0.017) of tumors. In survival analysis, upregulation of the three markers was additionally associated with shorter disease free survival (DFS, p = 0.001) and overall survival (OS, p = 0.002). High expression of all three markers was a strong independent prognostic factor for DFS (p = 0.030) and OS (p = 0.026).
CONCLUSIONS
Oral SCC with altered glycolytic metabolism exhibits a more invasive and aggressive phenotype. Our results indicate that glycolytic metabolism biomarkers related to HIF-1alpha may be independent prognostic factors in patients with oral SCC.
Keyword
MeSH Terms
-
Biomarkers
Carcinoma, Squamous Cell
Disease-Free Survival
Glycolysis
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Isoenzymes
L-Lactate Dehydrogenase
Oxidoreductases
Phenotype
Phosphotransferases
Prognosis
Protein-Serine-Threonine Kinases
Pyruvic Acid
Recurrence
Up-Regulation
Hypoxia-Inducible Factor 1, alpha Subunit
Isoenzymes
L-Lactate Dehydrogenase
Oxidoreductases
Phosphotransferases
Protein-Serine-Threonine Kinases
Pyruvic Acid
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Relationship between Expression of Hypoxia Inducible Factor-1alpha or Vascular Endothelial Growth Factor and Histopathological Characteristics in Human Renal Cell Carcinoma
- Expression of Hypoxia-inducible Factor-1 alpha Protein in Stages I and II Squamous Cell Carcinomas of the Uterine Cervix: Relationship with p53 Protein and VEGF Expressions
- Expression of Hypoxia-inducible Factor-1alpha in Esophageal Squamous Cell Carcinoma: Relationship to Prognosis and Tumor Biomarkers
- Immunohistochemical Expression and Prognostic Value of VEGF, HIF-1alpha, EGFR in Non-Small Cell Lung Cancer
- The Relationship between Expression of Hypoxia Inducible Factor-1alpha or Vascular Endothelial Growth Factor and Histopathological Characteristics in Human Transitional Bladder Cancer
