Korean J Otorhinolaryngol-Head Neck Surg.
2009 May;52(5):453-456. 10.3342/kjorl-hns.2009.52.5.453.
A Case of Leptomeningeal Carcinomatosis with Bilateral Hearing Loss and Dizziness
- Affiliations
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- 1Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. hyojlee@hallym.ac.kr
- 2Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
- KMID: 2277056
- DOI: http://doi.org/10.3342/kjorl-hns.2009.52.5.453
Abstract
- Leptomeningeal carcinomatosis is defined as the diffuse infiltration of the leptomeninges by malignant cells metastasized from systemic cancer. We report a case of leptomeningeal carcinomatosis presenting bilateral sensorineural hearing loss and dizziness. A 51-year-old woman who was diagnosed with non-small cell lung cancer with leptomeningeal carcinomatosis was referred to our department because of progressive hearing loss and dizziness. Magnetic resonance imaging revealed an abnormal enhancement of the vestibulocochlear nerves within the internal auditory canals bilaterally. The patient received chemotherapy concurrently with an intrathecal methotrexate injection. Leptomeningeal carcinomatosis must be considered in the differential diagnosis of cancer patients with bilateral progressive sensorineural hearing loss.
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