Korean J Otolaryngol-Head Neck Surg.
2004 Sep;47(9):868-871.
A Study of Susceptibility between Allergic Rhinitis and STAT6 Gene G2964A Polymorphism Study of a Korean Population
- Affiliations
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- 1Department of Otolaryngology, College of Medicine, Wonkwang University, School of medicine, Iksan, Korea. coolnose@wmc.wonkwang.ac.kr
- 2Department of Anatomy, College of Medicine, Wonkwang University, School of medicine, Iksan, Korea.
- 3Genomic Research Center for Immune Disorder, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, School of medicine, Iksan, Korea.
Abstract
- BACKGROUND AND OBJECTIVES
T helper-type 2 cytokines, such as IL-4 and IL-13, may play a central role in allergic diseases. The proteins known as signal transducers and activators of transcription 6 (STAT-6) are key transcription factors involved in both IL-4 and IL-13 mediated biological responses. Since a polymorphism of STAT6 G2964A has been found, we investigated the association between the polymorphism of STAT6 G2964A and allergic rhinitis in Korean. SUBJECTS AND METHOD: Blood samples for genetic analysis were obtained from 229 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for the STAT6 G2964A variant was used for genotyping. RESULTS: There were no differences in the frequencies of the genotypes between the controls and patients (p>0.05). The frequencies of the STAT6 2964A allele were not statistically different between controls and allergic rhinitis patients (p>0.05). CONCLUSION: Our result suggests that the STAT6 G2964A polymorphism might not give susceptibility to the development of allergic rhinitis in Koreans.
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