Korean J Otolaryngol-Head Neck Surg.
2002 Aug;45(8):796-804.
Mutation of p53 Gene and Infection of Human Papillomavirus in Oral and Oropharyngeal Carcinoma
- Affiliations
-
- 1Department of Otolaryngology-Head and Neck Surgery, Namkwang Hospital, College of Medicine, Seonam University, Kwangju, Korea. jschoi07@chollian.net
- 2Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chonnam National University, Kwangju, Korea.
- 3Department Pathology, College of Medicine, Chonnam National University, Kwangju, Korea.
Abstract
-
BACKGROUND AND OBJECTIVES: Oral and oropharyngeal squamous cell carcinomas (SCC) are diseases that are largely attributed to environmental exposure. Tobacco use and alcohol consumption are well-established risk factors. However, small proportions of oral and oropharyngeal SCCs occur also in nonsmokers and nondrinkers, suggesting the presence of other risk factors. We investigated etiologic role of Human papillomavirus (HPV) in patients with oral and oropharyngeal SCCs and the association between infection with HPV and p53 alteration in oral and oropharyngeal SCCs.
MATERIALS AND METHOD: Tumor tissues from 46 patients with oral and oropharyngeal SCCs were examined for the presence of HPV type 16 and 18 genome by polymerase chain reaction (PCR), and the p53 status of each tumor was analysed by sequencing and immunohistochemistry.
RESULTS
Thirty-six (78.3%) of 46 cases revealed overexpression of p53 protein and 14 (30.4%) had p53 mutation. The rate of p53 overexpression was much higher in smokers than in nonsmokers (p=0.003). HPV was detected in 8 (17.4%) of 46 cases and all were HPV type 16. As compared with HPV-negative carcinomas, HPV-positive cancers were less likely to occur among smokers (p=0.001) and to have p53 mutation and p53 overexpression (p=0.007), and had a moderately and poorly differentiated cancer characteristic.
CONCLUSION
The alteration of p53 is related to smoking which is counteractive to the presence of HPV infection, which can be considered as an independent etiologic factor in oral and oropharyngeal SCCs.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Angiogenesis and p53 Mutation in Oral and Oropharyngeal Squamous Cell Carcinoma
- Why Should You Care About Oral Gonorrhea and Oral Human Papillomavirus Infection?
- Analysis of p53 tumor suppressor gene mutations and human papillomavirus infection in human bladder cancers
- DETECT10N OF HUMAN PAPILLOMAVIRUS AND OVEREXPRESS1ON OF p53 IN SQUAMOUS CELL CARCINOMAS OF ORAL CAVITY
- Clinical Significance of Expression of p53 Oncoprotein and Human Papillomavirus in Cervical Cancer
