Korean J Pediatr Gastroenterol Nutr.  2010 Dec;13(Suppl 1):S25-S31. 10.5223/kjpgn.2010.13.Suppl1.S25.

Update on Genetic Studies of Functional Gastrointestinal Disorders

• Uhm JH

• KMID: 2275463
• DOI: http://doi.org/10.5223/kjpgn.2010.13.Suppl1.S25

Abstract

Childhood functional gastrointestinal disorders are defined as a variable combination of often age-dependent, chronic, or recurrent gastrointestinal symptoms not explained by structural or biochemical abnormalities. A better understanding of genetic background of these disorders would help to better identify their complex biology and make it possible to identify subgroups of patients who respond to customized therapies. Family and twin studies have shown a genetic component in irritable bowel syndrome. Candidate gene studies have identified a few genetic polymorphisms that may be associated with functional dyspepsia and irritable bowel syndrome. Studies of associations of spontaneous genetic variations and altered functions may provide novel insights of the mechanisms contributing to the disease.

Keyword

Irritable bowel syndrome; Functional dyspepsia; Candidate genes; Intermediate phenotypes

MeSH Terms

Biology
Dyspepsia
Gastrointestinal Diseases
Genetic Variation
Humans
Irritable Bowel Syndrome
Polymorphism, Genetic

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