Korean J Obstet Gynecol.  2010 Jul;53(7):608-615. 10.5468/kjog.2010.53.7.608.

Association of preterm birth with IFN-gamma, IL-10, and CYP 1A1 gene in Korean women

• You SY
• Kim JM
• Lee KA
• Park MH
• Kim YJ
• Chun SH

• KMID: 2273941
• DOI: http://doi.org/10.5468/kjog.2010.53.7.608

Abstract

OBJECTIVE
To investigate the association between preterm birth and cytokine genes (IFN-gamma, interleukin (IL)-10) in intrauterine infection and enzyme gene (CYP1A1) in oxidative stress response.
METHODS
This study involved a case-control study conducted at Ewha Womans University Hospital in Seoul, Korea. Subjects with preterm deliveries (<37 weeks of gestation) and normal controls with term deliveries (> or =37 weeks of gestation) were selected from gravidas who had undergone prenatal examinations in the hospital and were followed until infant delivery. The weight, height, and blood samples of each participants were obtained according to standard protocols. We included subjects who gave birth to a singleton infant and had a gestational age between 24 and 42 weeks. Mutiple births, stillbirths, and congenital anomalies were excluded. Finally, 164 gravidas with preterm births and 305 normal controls with term deliveries were enrolled in the present study.
RESULTS
Preterm delivery group and term delivery group had significant difference in gestational age and neonatal body weight (P<0.0001). There were no statistically significant association between preterm birth and IFN-gamma, IL-10, CYP1A1 genes (P>0.05).
CONCLUSION
In this study, IFN-gamma (874A/T), IL-10 (1082A/G), IL-10 (819C/T), IL-10 (592A/C) and CYP1A1 (T6235C), CYP1A1 (Ile462val [A/G]) genes had no significant association with preterm birth.

Keyword

Preterm birth; IFN-gamma; IL-10; CYP1A1 gene

MeSH Terms

Body Weight
Case-Control Studies
Cytochrome P-450 CYP1A1
Female
Gestational Age
Humans
Infant
Interleukin-10
Interleukins
Korea
Oxidative Stress
Parturition
Premature Birth
Stillbirth
Cytochrome P-450 CYP1A1
Interleukin-10
Interleukins

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