Korean J Obstet Gynecol.  2004 Dec;47(12):2308-2312.

Expression of Aquaporin-8 in Placenta of Preeclampsia

Affiliations
  • 1Department of Obstetrics and Gynecology, Chungbuk National University Hospital, Cheongju, Korea.

Abstract


OBJECTIVE
This study was to determine whether aquaporin-8, which plays a role as a transcellular water channel, is expressed in human placenta, and to compare the degree of its expression between preeclamptic women and normal pregnant women.
METHODS
Placentas were obtained from severely preeclamptic women and normal pregnant women who were delivered babies by cesarean section before the onset of labor in the Chungbuk National University Hospital. In situ hybridization with aquaporin-8 cRNA probe was performed using paraffin-embedded tissue section. Signal of aquaporin-8 expression was observed with light microscope.
RESULTS
In situ hybridization demonstrated strong expression of aquaporin-8 mRNA in the placentas of both preeclamptic women and normal pregnant women. The degree of expression was the same in both group.
CONCLUSION
Aquaporin-8 in human placenta may not be related to the pathogenesis of preeclampsia.

Keyword

Preeclampsia; Aquaporin-8; In situ hybridization

MeSH Terms

Cesarean Section
Chungcheongbuk-do
Female
Humans
In Situ Hybridization
Placenta*
Pre-Eclampsia*
Pregnancy
Pregnant Women
RNA, Complementary
RNA, Messenger
Water
RNA, Complementary
RNA, Messenger
Water
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