Korean J Obstet Gynecol.  2006 Jan;49(1):49-54.

Expression of Aquaporin-4 in Placenta of Preeclampsia

• Lee IH
• Kim MG
• Kim YR
• Hong SH
• Park YJ
• Ji IW
• Jeong EH
• Kim HS

Abstract

OBJECTIVE
This study was to determine whether aquaporin-4, which plays role as a transcellular water channel, is expressed in human placenta, and to compare the degree of its expression between preeclamptic women and normal pregnant women.
METHODS
Placentas were obtained from severely preeclamptic women and normal pregnant women who were delivered neonates by cesarean section before the onset of labor in the Chungbuk National University Hospital. Immunohistochemistry with aquaporin-4 antibody was performed using paraffin-embedded tissue section. Signal of aquaporin-4 expression was observed with light microscope.
RESULTS
Immunohistochemistry demonstrated expression of aquaporin-4 in the placentas of both preeclamptic women and normal pregnant women. The degree of expression was not different in both group.
CONCLUSION
Aquaporin-4 was expressed in the human placenta, but may not be related to the pathogenesis of preeclampsia.

Keyword

Preeclampsia; Aquaporin-4; Immunohistochemistry

MeSH Terms

Cesarean Section
Chungcheongbuk-do
Female
Humans
Immunohistochemistry
Infant, Newborn
Placenta*
Pre-Eclampsia*
Pregnancy
Pregnant Women