Korean J Nutr.  2006 Jan;39(1):11-17.

Effect of Dietary Caseinphosphopeptide Levels on Bone Metabolism in Ovariectomized Rats

• Yang D
• Lee JW
• Park HJ
• Kim SH
• Chang MJ

Abstract

The effect of the level of casein phosphopeptide (CPP) on mineral (Ca and P) bioavailabilties and bone biomarker of aged ovariectomized (OVX) Sprague-Dawley rats were studied as a model for postmenopausal bone loss. Forty five Spargue dawley rats, 220-230g of body weight were fed a control diet (AIN 93M) or containing different level of CPP diet for 7 weeks: 0% (sham control; SC, OVX control; OC), 1% (OVX low CPP diet; OL), 2% (OVX medium CPP diet; OM), 3% (OVX high CPP diet; OH) Ca absorption was unaffected by increasing CPP content from 0 to 3%. Urinary Ca excretion was increased by OVX, and decreased by CPP significantly (p<0.05) with no evident dose-relationship. The urinary P excretion was increased by CPP intake in OVX rats. The fecal excretion of P given CPP decreased in OVX with dose dependent manner. Ca and P contents of femur significantly increased by adding 2 or 3% of CPP when compared with OC group and OL group (p<0.05). There were no significant differences in serum alkaline phosphatase activity and c-terminal telopeptide excretion in experimental groups. Although ovariectomy induced the increase in urinary c-terminal telopeptide excretion, 2 or 3% of CPP in the diet decreased urinary c-terminal telopetide excretion significantly. These finding suggest the usefulness of CPP in the prevention of postmenopausal bone loss by decreasing urinary Ca excretion and bone resorption. Over 2 percent of CPP in the diet was effective to prevent postmenopausal bone loss.

Keyword

casein phophopeptides; calcium; phosphorus; bone biomarkers; ovariectomized rats

MeSH Terms

Absorption
Alkaline Phosphatase
Animals
Body Weight
Bone Resorption
Calcium
Caseins
Diet
Female
Femur
Humans
Metabolism*
Osteoporosis, Postmenopausal
Ovariectomy
Phosphorus
Rats*
Rats, Sprague-Dawley
Alkaline Phosphatase
Calcium
Caseins
Phosphorus