Korean J Med.  2015 Feb;88(2):218-223. 10.3904/kjm.2015.88.2.218.

Successful Salvage Treatment for Isolated Brain Parenchymal Relapse due to Diffuse Large B Cell Lymphoma

• Kim SG
• Bae SH
• Ryoo HM

• KMID: 2269156
• DOI: http://doi.org/10.3904/kjm.2015.88.2.218

Abstract

A central nervous system (CNS) relapse is a rare but mostly fatal complication in patients with diffuse large B cell lymphoma (DLBCL). CNS involvement can occur as an isolated event or can be combined with progression of systemic disease. There are limited data on treatment outcomes of patients with DLBCL and secondary CNS involvement. We report the clinical data, treatments, and outcomes of two DLBCL patients with isolated CNS relapses involving the brain parenchyma. Isolated CNS disease involving the brain parenchyma may be potentially treatable as the initial relapse site after complete remission from systemic treatment.

Keyword

Diffuse large cell lymphoma; Central nervous system; Relapse

MeSH Terms

Brain*
Central Nervous System
Central Nervous System Diseases
Humans
Lymphoma, B-Cell*
Lymphoma, Large B-Cell, Diffuse
Recurrence*