Korean J Med.  2015 Apr;88(4):469-474. 10.3904/kjm.2015.88.4.469.

A Case of Sequential Lymphoma in an Human Immunodeficiency Virus-Infected Patient

• Jung YN
• Lee JR
• Lee HS
• Jin BS
• Seo CI
• Shin HS
• Jung EJ

• KMID: 2269136
• DOI: http://doi.org/10.3904/kjm.2015.88.4.469

Abstract

Rarely, two different histological types of lymphoma develop in the same person. Sequential lymphoma is defined as two different types of lymphoma occurring in the same person sequentially. A 47-year-old patient with human immunodeficiency virus (HIV) infection who had been diagnosed with mixed cellularity Hodgkin's lymphoma was treated with adriamycin, bleomycin, vinblastine, and dacarbazine combination chemotherapy. After six cycles of chemotherapy, abdominal computed tomography showed multiple liver masses. A percutaneous needle biopsy of the liver and polymerase chain reaction single-strand conformation polymorphism revealed hepatosplenic T-cell lymphoma. The patient died 3 months after the diagnosis of hepatosplenic T-cell lymphoma. To our knowledge, this is the first case of the sequential development of hepatosplenic T-cell lymphoma after Hodgkin's lymphoma in a Korean HIV-infected patient.

Keyword

Human immunodeficiency virus; Hodgkin's lymphoma; T-cell lymphoma

MeSH Terms

Biopsy, Needle
Bleomycin
Dacarbazine
Diagnosis
Doxorubicin
Drug Therapy
Drug Therapy, Combination
HIV
Hodgkin Disease
Humans
Liver
Lymphoma*
Lymphoma, T-Cell
Middle Aged
Polymerase Chain Reaction
Vinblastine
Bleomycin
Dacarbazine
Doxorubicin
Vinblastine