Korean J Med.
2015 Apr;88(4):363-368. 10.3904/kjm.2015.88.4.363.
Acute Kidney Injury: New Biomarkers
- Affiliations
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- 1Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea. kidney@jbnu.ac.kr
- KMID: 2269118
- DOI: http://doi.org/10.3904/kjm.2015.88.4.363
Abstract
- Acute kidney injury (AKI) has various triggers, such as ischemia, nephrotoxins, radiocontrast, and bacterial endotoxins. It occurs in about one-third of patients treated in the intensive care unit. There is a higher mortality in patients with AKI compared with their non-AKI counterparts. The diagnosis of AKI usually depends on serum creatinine (SCr) measurements. However, SCr is a delayed and unreliable indicator of AKI. The lack of early biomarkers has limited the ability to manage AKI. Fortunately, understanding the early stress response of the kidney to injury has resulted in the identification and validation of several potential novel urine and blood biomarkers. Recently, new biomarkers of AKI with more favorable characteristics than SCr have been identified and studied in various experimental and clinical settings. This article reviews the most well-established biomarkers of AKI.
