Korean J Med.
2015 Jun;88(6):732-736. 10.3904/kjm.2015.88.6.732.
Allergic Reaction to Meperidine in a Patient with Aspirin Idiosyncrasy
- Affiliations
-
- 1Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. chansun@paik.ac.kr
- 2Department of Otorhinolaryngology-Head and Neck Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
- 3Department of Anesthesiology and Pain Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
- 4Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
- KMID: 2269092
- DOI: http://doi.org/10.3904/kjm.2015.88.6.732
Abstract
- Although narcotic analgesics are potent releasers of histamine, IgE-mediated allergic reactions to these drugs are rare. Here we report the case of a 56-year-old male who suffered from chronic urticarial and analgesics-induced skin rashes. He visited our allergy clinic to determine alternative analgesics before undergoing surgery. A drug provocation test showed a positive reaction to aspirin, but negative reactions to acetaminophen and celecoxib. Despite careful attention to his drug regimen, during surgery he developed generalized urticaria and flushing. Skin tests of allergy to latex, lidocaine, propofol, rocuronium, flomoxef, meperidine, palonosetron, pyridostigmine, and fentanyl yielded negative results, except for the prick and intradermal tests with meperidine. Thus, this patient had both an aspirin/non-steroidal anti-inflammatory drugs idiosyncrasy and an IgE-mediated hypersensitivity to meperidine.
Keyword
MeSH Terms
-
Acetaminophen
Analgesics
Aspirin*
Exanthema
Fentanyl
Flushing
Histamine
Humans
Hypersensitivity*
Hypersensitivity, Immediate
Intradermal Tests
Latex
Lidocaine
Male
Meperidine*
Middle Aged
Narcotics
Propofol
Pyridostigmine Bromide
Skin Tests
Urticaria
Celecoxib
Acetaminophen
Analgesics
Aspirin
Fentanyl
Histamine
Latex
Lidocaine
Meperidine
Narcotics
Propofol
Pyridostigmine Bromide
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