Korean J Med.
2013 Feb;84(2):303-307.
A Case of Sunitinib-Associated Thrombotic Thrombocytopenic Purpura
- Affiliations
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- 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jaelyun@amc.seoul.kr
Abstract
- Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP-HUS) is an acute condition with abnormalities of multiple organ systems. It is characterized by microangiopathic hemolytic anemia and thrombocytopenia. Several chemotherapeutic agents have been implicated in causing TTP-HUS. We report a case of TTP-HUS during treatment with sunitinib in a patient with metastatic renal cell carcinoma. A 53-year-old woman visited our hospital for fever and cough. She was diagnosed with sunitinib-induced TTP. Discontinuation of sunitinib and plasmapheresis improved her TTP. When she experienced disease progression after a prolonged period without treatment, sorafenib was tried, resulting in a partial response without recurrence of TTP-HUS.
MeSH Terms
-
Anemia, Hemolytic
Carcinoma, Renal Cell
Cough
Disease Progression
Female
Fever
Hemolytic-Uremic Syndrome
Humans
Indoles
Niacinamide
Phenylurea Compounds
Plasmapheresis
Purpura, Thrombotic Thrombocytopenic
Pyrroles
Recurrence
Thrombocytopenia
Thymine Nucleotides
Indoles
Niacinamide
Phenylurea Compounds
Pyrroles
Thymine Nucleotides
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