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Prognostic utility of ADAMTS13 activity for the atypical hemolytic uremic syndrome (aHUS) and comparison of complement serology between aHUS and thrombotic thrombocytopenic purpura

Oh J, Oh D, Lee SJ, Kim JO, Kim NK, Chong SY, Huh JY, Baker RI, on behalf of the Korean TTP Registry Investigators

BACKGROUND: Atypical hemolytic uremic syndrome (aHUS) involves dysregulation of the complement system, but whether this also occurs in thrombotic thrombocytopenic purpura (TTP) remains unclear. Although these conditions are difficult to...
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Differential Diagnosis and Treatment of Thrombotic Microangiopathy Syndrome

Hong J

Diagnosis of thrombotic microangiopathy (TMA) is challenging due to its close association with other forms of microangiopathic hemolytic anemia, such as malignant hypertension and disseminated intravascular coagulation, and because other...
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A Case of Thrombotic Thrombocytopenic Purpura with Exacerbation after Incomplete Remission of Therapeutic Plasma Exchange

Sohn YH, Ihm C, Choi EH, Lee SK

Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder with a mortality rate of over 90% without prompt treatment. It is caused by congenital, idiopathic, or secondary diseases; idiopathic TTP...
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Thrombotic Thrombocytopenic Purpura Associated with Bone Marrow Necrosis Complicating Metastatic Extra-Mammary Paget's Disease

Sohn JM, Lee JL, Kim BJ, Song KM, Cho YU, Kim EN, Hong JH

As extra-mammary Paget's disease is rare and usually diagnosed at early stage when it is highly curable with surgical resection, it is much rarer to see patients with recurrent metastatic...
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A Case of Rheumatoid Arthritis Accompanied by Thrombotic Thrombocytopenic Purpura

Kang SM, Lee JH, Ku IH, Kim HK, Nam KS, Park SK

Thrombotic thrombocytopenic purpura (TTP) is a blood coagulation disorder that damages numerous organs, including the kidney, heart and brain. Features indicative of TTP include thrombocytopenia, microangiopathic hemolytic anemia, neurologic symptoms,...
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Thrombotic Thrombocytopenic Purpura and Rhabdomyolysis Associated With Acute Renal Failure in Hypothyroidism

Lee J, Lee KW, Yun SM, Shin HC, Nam SM, Cho NY

Myopathy due to hypothyroidism can be detected in its early stage, but as the symptom is mild, complications such as rhabdomyolysis are rare. Thrombotic thrombocytopenic purpura in hypothyroidism is not...
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A Case of Thrombotic Thrombocytopenic Purpura associated with Clopidogrel in a Patient with Acute Cerebral Infarction

Park J, Lee Y, Park H, Min J, Ko Y, Kim YO

Clopidogrel is an antiplatelet agent prescribed widely to prevent stent thrombosis after coronary or peripheral vascular interventions and for stroke prophylaxis. The side effects of this drug include gastrointestinal symptoms,...
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A Postoperative Thrombotic Thrombocytopenic Purpura in a Cardiac Surgery Patient: A Case Report

Choi EJ, Lee S

Although thrombotic thrombocytopenic purpura (TTP) is a rare disease, when it develops in a post-cardiac surgery patient, it may have a fatal outcome. Since the frequency of early-onset thrombocytopenia in...
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A Case of Sunitinib-Associated Thrombotic Thrombocytopenic Purpura

Kim EJ, Choi YM, Lee SW, Ha YJ, Lee JL

  • KMID: 2267896
  • Korean J Med.
  • 2013 Feb;84(2):303-307.
Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP-HUS) is an acute condition with abnormalities of multiple organ systems. It is characterized by microangiopathic hemolytic anemia and thrombocytopenia. Several chemotherapeutic agents...
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Plasma Exchange for Patients with Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome (TTP-HUS) in Pusan National University Hospital (2003~2011)

Shin KH, Lee HJ, Kim SY, Chang CL, Park KH, Lee EY, Son HC, Kim HH

  • KMID: 1440721
  • Korean J Blood Transfus.
  • 2012 Apr;23(1):48-57.
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are related diseases with high rates of fatality. Plasma exchange therapy improves survival rates in patients with TTP and HUS....
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Slow, but complete, resolution of mitomycin-induced refractory thrombotic thrombocytopenic purpura after rituximab treatment

Hong MJ, Lee HG, Hur M, Kim SY, Cho YH, Yoon SY

Thrombotic thrombocytopenic purpura (TTP) is a critical complication of treatment with mitomycin C. We retrospectively describe the case of a patient with progressive renal cell carcinoma and mitomycin-induced TTP refractory...
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Thrombotic thrombocytopenic purpura in three pregnancies

Yoon WS, Lee JW, Kim YH, Ahn HY, Shin JC

Thromobotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS), characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, central nervous system abnormalities, and renal dysfunction, is severe multisystem disorder. TTP-HUS occurs predominantly in the reproductive...
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A Case Report of Rituximab Therapy for Recurrent Thrombotic Thrombocytopenia Purpura

Lee S, Lee JH, Choi Y, Yu JH, Chun YH, Choi WJ, Jung SS

Thrombotic thrombocytopenic purpura (TTP) is a rare medical condition characterized by thrombocytopenia, microangiopathic hemolytic anemia, neurologic manifestations, and infrequently, renal involvement. In many cases, TTP is associated with deficiency of...
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Thrombotic Thrombocytopenic Purpura Induced by Trimethoprim-Sulfamethoxazole in a Patient with Rheumatoid Arthritis

Sohn JY, Lee KA, Hong YK, Yoo WH

  • KMID: 2334880
  • J Korean Rheum Assoc.
  • 2009 Dec;16(4):296-300.
Thromobotic thrombocytopenic purpura (TTP) is a multisystem disorder that's characterized by consumptive thrombocytopenia, microangiopathic hemolytic anemia,and neurologic symptoms. TTP is associated with many diseases and several therapeutic drugs. We report...
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High-dose Immunoglobulin Infusion for Thrombotic Thrombocytopenic Purpura Refractory to Plasma Exchange and Steroid Therapy

Park SJ, Kim SJ, Seo HY, Jang MJ, Oh D, Kim BS, Kim JS

The outcomes of the treatment of thrombotic thrombocytopenic purpura (TTP) have been shown to be improved by the administration of plasma exchange. However, treatment options are currently limited for cases...
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Thrombotic Thrombocytopenic Purpura that Developed after Rectal Cancer Surgery

Kim DD, Shin US, Yoon SN, Yu CS, Kim JC

  • KMID: 2211213
  • J Korean Surg Soc.
  • 2008 Jun;74(6):452-455.
Thrombotic thrombocytopenic purpura (TTP) in the acute postoperative setting is a syndrome that presents with various symptoms such as microangiopathic hemolytic anemia, thrombocytopenia, fever, renal failure, and change of the...
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A Case of Splenectomy in a Patient with Refractory Thrombotic Thrombocytopenic Purpura

Lee JW, Kim SC, Oh SW, Cha JJ, Kim HW, Boo CS, Lee JE, Kwon YJ, Pyo HJ

  • KMID: 2253321
  • Korean J Nephrol.
  • 2008 Mar;27(2):243-247.
The introduction of plasma exchange has significantly improved the outcome of thrombotic thrombocytopenic purpura (TTP) and the survival rate was increased from 10 to 80-90%. TTP refractory to plasma exchange...
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Clinical outcomes of renal patients treated with therapeutic plasma exchange

Lee SY, Kim NH, Jeong S, Jang DS, Lee YM, Na KR, Lee KW, Shin YT

  • KMID: 2305917
  • Korean J Med.
  • 2007 Aug;73(2):176-182.
BACKGROUND: Therapeutic plasma exchange (TPE) is a procedure by which plasma is removed from whole blood and this can be used in the treatment of some renal diseases. METHODS: We reviewed...
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Two Cases of Thrombotic Thrombocytopenic Purpura in Systemic Lupus Erythematosus

Kim HY, Kim HH, Kim SY

  • KMID: 2322137
  • J Korean Soc Pediatr Nephrol.
  • 2007 Oct;11(2):288-293.
Thrombotic thrombocytopenic purpura(TTP) is a rare but life-threatening multi-system disorder characterized by the classic pentad of clinical features that includes fever, microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities and renal dysfunction....
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Hemolytic uremic syndrome

Park HW

The hemolytic uremic syndrome (HUS) is a rare disease of microangiopathic hemolytic anemia, low platelet count and renal impairment. HUS usually occurs in young children after hemorrhagic colitis by shigatoxin-producing...
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