Ann Dermatol.  2013 Feb;25(1):17-22. 10.5021/ad.2013.25.1.17.

The Clinical Efficacy of Mometasone Furoate in Multi-Lamellar Emulsion for Eczema: A Double-blinded Crossover Study

Affiliations
  • 1Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea. drchosh@hotmail.com
  • 2Department of Dermatology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
  • 3Department of Dermatology, College of Medicine, Seoul National University, Seoul, Korea.
  • 4Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
  • 5Department of Dermatology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.

Abstract

BACKGROUND
Topical application of corticosteroids also has an influence on skin barrier impairment. Physiological lipid mixtures, such as multi-lamellar emulsion (MLE) containing a natural lipid component leads to effective recovery of the barrier function.
OBJECTIVE
The purpose of this study was to conduct an evaluation of the therapeutic efficacy and skin barrier protection of topical mometasone furoate in MLE.
METHODS
A multi-center randomized, double-blind, controlled study was performed to assess the efficacy and safety of mometasone furoate cream in MLE for Korean patients with eczema. The study group included 175 patients with eczema, who applied either mometasone furoate in MLE cream or methylprednisolone aceponate cream for 2 weeks. Treatment efficacy was evaluated using the physician's global assessment of clinical response (PGA), trans-epidermal water loss (TEWL), and visual analogue scale (VAS) for pruritus. Patients were evaluated using these indices at days 4, 8, and 15.
RESULTS
Comparison of PGA score, TEWL, and VAS score at baseline with those at days 4, 8, and 15 of treatment showed a significant improvement in both groups. Patients who applied mometasone furoate in MLE (74.8%) showed better results (p<0.05) than those who applied methylprednisolone aceponate (47.8%). The TEWL improvement ratio was higher in the mometasone furoate in MLE group than that in the methylprednisolone aceponate group, and VAS improvement was also better in the mometasone furoate in MLE group.
CONCLUSION
Mometasone furoate in MLE has a better therapeutic efficacy as well as less skin barrier impairment than methylprednisolone aceponate.

Keyword

Ceramide; Corticosteroid; Eczema; Multi-lammelar emulsion; Skin-barrier

MeSH Terms

Adrenal Cortex Hormones
Cross-Over Studies
Eczema
Humans
Methylprednisolone
Pregnadienediols
Prostaglandins A
Pruritus
Skin
Treatment Outcome
Water Loss, Insensible
Mometasone Furoate
Adrenal Cortex Hormones
Methylprednisolone
Pregnadienediols
Prostaglandins A
Water Loss, Insensible

Figure

  • Fig. 1 The physician's global assessment of clinical response (PGA) improvement ratio at day 4, 8, 15. Comparison of the PGA improvement ratio between themometasone furoate in multi-lamella emulsion (MLE) group and the methylprednisolone group. A significant difference was observed in the PGA improvement ratio at all follow-up periods (p≤0.0001).

  • Fig. 2 The trans-epidermal water loss (TEWL) improvement ratio. Comparison of the TEWL improvement ratio between the mometasone furorate in multi-lamella emulsion (MLE) group and the methylprednisolone group. A significant difference was observed in the TEWL improvement ratio at all follow-up periods (p≤0.0001).

  • Fig. 3 The visual analog scale (VAS) improvement ratio. Comparison of the VAS improvement ratio between the mometasone furorate in multi-lamella emulsion (MLE) group and the methylprednisolone group. A significant difference was observed in the VAS improvement ratio at day 15 (p≤0.0001).


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