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Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease

Song JH, Kim GT, Park KH, Park WJ, Park TS

  • KMID: 2517155
  • Biomol Ther.
  • 2021 Jul;29(4):373-383.
Atherosclerosis is the deposition of plaque in the main arteries. It is an inflammatory condition involving the accumulation of macrophages and various lipids (low-density lipoprotein [LDL] cholesterol, ceramide, S1P). Moreover,...
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Case-Control Study: The Effects of Synthetic Ceramide on Dandruff, Erythema, Sebum Secretion and Water Loss of Scalp

Park HR, Jeong KH, Kim JE, Kang H

  • KMID: 2516140
  • Korean J Dermatol.
  • 2021 May;59(4):277-283.
Background: Ceramide offers an important barrier function to the epidermis. It can reduce epidermal water loss and inhibit the production of dandruff. Ceramide is essential in protecting hair and can...
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Ceramide/Sphingomyelin Rheostat Regulated by Sphingomyelin Synthases and Chronic Diseases in Murine Models

Taniguchi M, Okazaki T

Ceramide and sphingomyelin (SM) are major components of the double membranebound sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes including apoptosis, necrosis, and autophagy-dependent cell death....
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Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy

Woo CY, Baek JY, Kim AR, Hong CH, Yoon JE, Kim HS, Yoo HJ, Park TS, Kc R, Lee KU, Koh EH

BackgroundCeramides are associated with metabolic complications including diabetic nephropathy in patients with diabetes. Recent studies have reported that podocytes play a pivotal role in the progression of diabetic nephropathy. Also,...
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Hepatic Expression of the Serine Palmitoyltransferase Subunit Sptlc2 Reduces Lipid Droplets in the Liver by Activating VLDL Secretion

Kim GT, Kim SJ, Park SH, Lee D, Park TS

Objective: Ceramide is a signaling molecule that contributes to insulin resistance and hepatosteatosis. In the present study, we activated de novo ceramide synthesis by inducing the hepatic expression of Sptlc2...
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The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond

Moon JS, Karunakaran U, Suma E, Chung SM, Won KC

Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential...
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Ceramides: Nutrient Signals that Drive Hepatosteatosis

Summers SA

Ceramides are minor components of the hepatic lipidome that have major effects on liver function. These products of lipid and protein metabolism accumulate when the energy needs of the hepatocyte...
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Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model

Kim M, Jeong H, Lee B, Cho Y, Yoon WK, Cho A, Kwon G, Nam KT, Ha H, Lim KM

Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in...
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Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

Oh JH, Jeong KH, Kim JE, Kang H

BACKGROUND: The ceramide is known to play an important role in the formation of intracellular lipids, and play a crucial role as a barrier for skin and hair cuticle. Recent...
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Development of a Label-Free LC-MS/MS-Based Glucosylceramide Synthase Assay and Its Application to Inhibitors Screening for Ceramide-Related Diseases

Fu Z, Yun SY, Won JH, Back MJ, Jang JM, Ha HC, Lee HK, Shin IC, Kim JY, Kim HS, Kim DK

Ceramide metabolism is known to be an essential etiology for various diseases, such as atopic dermatitis and Gaucher disease. Glucosylceramide synthase (GCS) is a key enzyme for the synthesis of...
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Associations among plasma vitamin C, epidermal ceramide and clinical severity of atopic dermatitis

Shin J, Kim YJ, Kwon O, Kim NI, Cho Y

BACKGROUND/OBJECTIVES: Atopic dermatitis (AD), a chronic inflammatory skin disease, is accompanied by disruption of the epidermal lipid barrier, of which ceramide (Cer) is the major component. Recently it was reported...
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Comparative effect of dietary borage oil and safflower oil on anti-proliferation and ceramide metabolism in the epidermis of essential fatty acid deficient guinea pigs

Lee SR, Cho Y

PURPOSE: Borage oil (BO) and safflower oil (SO) are efficacious in reversing epidermal hyperproliferation, which is caused by the disruption of epidermal barrier. In this study, we compared the antiproliferative...
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Vitamin C Stimulates Epidermal Ceramide Production by Regulating Its Metabolic Enzymes

Kim KP, Shin KO, Park K, Yun HJ, Mann S, Lee YM, Cho Y

Ceramide is the most abundant lipid in the epidermis and plays a critical role in maintaining epidermal barrier function. Overall ceramide content in keratinocyte increases in parallel with differentiation, which...
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Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

Sassa T, Kihara A

  • KMID: 2170646
  • Biomol Ther.
  • 2014 Mar;22(2):83-92.
Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found...
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Induction of a Hardening Phenomenon and Quantitative Changes of Ceramides in Stratum Corneum

Park SY, Kim JH, Cho SI, Kim KI, Cho HJ, Park CW, Lee CH, Kim HO

BACKGROUND: Hardening phenomenon of human skin after repeated exposure to the irritants is well-known, but the precise mechanism remains elusive. OBJECTIVE: To modify the previous experimental model of hardening phenomenon by...
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Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis

Moon SH, Kim JY, Song EH, Shin MK, Cho YH, Kim NI

BACKGROUND: Ceramides are the main lipid component of the stratum corneum and are a structurally heterogeneous and complex group of sphingolipids of which sphingoid bases are the basic structural constituents....
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Clinical use of a ceramide-based moisturizer for treating dogs with atopic dermatitis

Jung JY, Nam EH, Park SH, Han SH, Hwang CY

In humans, skin barrier dysfunction is thought to be responsible for enhanced penetration of allergens. Similar to conditions seen in humans, canine atopic dermatitis (CAD) is characterized by derangement of...
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Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides

Hwang YJ, Park SM, Yim CB, Im C

B13 is a ceramide analogue and apoptosis inducer with potent cytotoxic activity. A series of arylpropyl sulfonamide analogues of B13 were evaluated for their cytotoxicity using MTT assays in prostate...
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Atopic dermatitis and skin barrier dysfunction

Kim H, Shin JU, Lee KH

Atopic dermatitis is a chronic relapsing eczematous dermatosis, which usually starts in childhood, and various causes are intricately associated with the development of the disease. Recently, various abnormalities in barrier...
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The Clinical Efficacy of Mometasone Furoate in Multi-Lamellar Emulsion for Eczema: A Double-blinded Crossover Study

Kim DH, Lee HJ, Park CW, Kim KH, Lee KH, Ro BI, Cho SH

BACKGROUND: Topical application of corticosteroids also has an influence on skin barrier impairment. Physiological lipid mixtures, such as multi-lamellar emulsion (MLE) containing a natural lipid component leads to effective recovery...
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