Korean J Dermatol.  2015 Jun;53(5):347-350.

The Effect of Mometasone Furoate Cream on Skin Barrier Function in Patients with Allergic Contact Dermatitis

• So BJ
• Park JB
• Chun SH
• Son SW

Abstract

BACKGROUND
It is unclear how the usage of topical steroid agents affects skin barrier function.
OBJECTIVE
In order to follow up on previous research into this topic, we sought to investigate the effects of a 3-week application of topical mometasone cream on the alteration of skin barrier function.
METHODS
Twenty-six patients who had been clinically diagnosed with allergic contact dermatitis were enrolled. Topical mometasone cream was applied to the skin lesions. Clinical symptoms, transepidermal water loss (TEWL), corneometer unit, and pH value were measured on the initial visit, 1 week after treatment, and 3 weeks after treatment, and their values were compared.
RESULTS
Clinical symptoms showed improvement after topical mometasone cream was applied (p<0.05), but changes in TEWL, corneometer units, and pH values failed to show statistical significance (p>0.05).
CONCLUSION
This study found that treatment with topical mometasone cream for 3 weeks has no effect on skin barrier function. We believe that this research will help determine the optimal duration and dosage of topical steroid agents used for treating allergic contact dermatitis.

Keyword

Skin barrier; Mometasone furoate; Contact dermatitis; Transepidermal water loss (TEWL); Corneometer

MeSH Terms

Dermatitis, Allergic Contact*
Dermatitis, Contact
Follow-Up Studies
Humans
Hydrogen-Ion Concentration
Skin*
Mometasone Furoate