Korean J Dermatol.  2009 Jun;47(6):710-713.

A Case of Allergic Contact Dermatitis from Silmazine(R) Cream

• Kang MC
• Kim SA
• Chung SL
• Lee KS

Abstract

Silmazine(R) cream is an antibiotic agent widely used in burn therapy. It consists of Propylene glycol, Stearyl alcohol, Isopropyl Myristate, Sorbitan mono-oleate, Methyl-p-hydroxybenzoate, Polyoxyl 40 stearate and varseline. A 24-year- old female presented with well-demarcated erythematous papules and vesicles with an itching sensation on the dorsal area of her right hand. She had applied Silmazine(R) cream on the dorsal area of her right handfor 4 days and the skin lesion became aggravated. A patch test with Silmazine(R) cream 'as is' showed a positive reaction and propylene glycol and stearyl alcohol, ingredients in Silmazine(R) cream, revealed a positive reaction. These two agents are known as weak sensitizers that can produce allergic contact dermatitis. There are some reports of allergic contact dermatitis from propylene glycol and stearyl alcohol used topically. As far as we know, there are no reports of allergic contact dermatitis from propylene glycol and stearyl alcohol in the Silmazine(R) cream (Silver sulfadiazine) that is commonly used as topical antibiotic medication for burns. We report this rare case of allergic contact dermatitis from propylene glycol and stearyl alcohol in Silmazine(R) cream (Silver sulfadiazine).

Keyword

Allergic contact dermatitis; Propylene glycol; Silmazine(R) cream; Stearyl alcohol

MeSH Terms

2-Propanol
Alkenes
Burns
Dermatitis, Allergic Contact
Fatty Alcohols
Female
Hand
Humans
Myristates
Myristic Acid
Patch Tests
Propylene Glycol
Pruritus
Sensation
Skin
2-Propanol
Alkenes
Fatty Alcohols
Myristates
Myristic Acid
Propylene Glycol