Ann Dermatol.  2013 Nov;25(4):493-495. 10.5021/ad.2013.25.4.493.

A Granulomatous Drug Eruption Induced by Entecavir

Affiliations
  • 1Department of Dermatology, Gyeongsang National University Hospital, Jinju, Korea. cykim@gnu.ac.kr
  • 2Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.

Abstract

Entecavir (Baraclude(R), Bristol-Myers Squibb) is a potent and selective antiviral agent that has demonstrated efficacy in patients with chronic hepatitis B. The most frequent adverse events attributed to entecavir include increased alanine aminotransferase, upper respiratory tract infection, headache, abdominal pain, cough, pyrexia, fatigue, and diarrhea. Although quite a few randomized double-blind studies including ones investigating adverse events along with these general symptoms have been reported, few cases of cutaneous adverse events have been described in detail. We demonstrate a case of granulomatous drug eruption as a cutaneous adverse event induced by entecavir.

Keyword

Drug eruptions; Entecavir

MeSH Terms

Abdominal Pain
Alanine Transaminase
Cough
Diarrhea
Double-Blind Method
Drug Eruptions*
Fatigue
Fever
Guanine
Headache
Hepatitis B, Chronic
Humans
Respiratory Tract Infections
Alanine Transaminase
Guanine

Figure

  • Fig. 1 (A) The patient presented with multiple pruritic erythematous papules on the forehead, both periorbital areas and cheeks 2 months after initiating entecavir therapy. (B) Closed view. (C) Resolved state after discontinuation of the entecavir.

  • Fig. 2 (A) Histopathologic findings showed rosaceiform granulomatous inflammatory reactions in the dermis and subcutis (H&E, ×40). (B) The infiltration of lymphocytes and epithelioid histiocytes were seen in the perivascular area (H&E, ×100).


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