Korean J Med.
2012 Sep;83(3):363-368.
A Case Report of Methimazole-Induced Acute Liver Failure Successfully Treated with Liver Transplantation
- Affiliations
-
- 1Department of Internal Medicine, Ulsan University College of Medicine, Seoul, Korea. tykim@amc.seoul.kr
- 2Department of Surgery, Ulsan University College of Medicine, Seoul, Korea.
- 3Department of Pathology, Ulsan University College of Medicine, Seoul, Korea.
Abstract
- Antithyroid drugs inhibit the synthesis and excretion of thyroid hormone from the thyroid gland. Propylthiouracil (PTU) and methimazole are well known as antithyroid drugs. In 2011, the American Thyroid Association and American Association of Clinical Endocrinologists published management guidelines for hyperthyroidism and other causes of thyrotoxicosis, and recommended methimazole as the first-choice antithyroid drug for the treatment of hyperthyroidism. Lower hepatotoxicity is an advantage of methimazole. Fulminant hepatitis rarely occurs in methimazole users, and spontaneous recovery is expected even if it does occur. We describe a rare case of acute liver failure after methimazole intake in a 60-year-old man who underwent liver transplantation.
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