- A case of Methimazole-Induced Cholestatic Jaundice With Agranulocytosis
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Kang SG, Bae JO, Lee EY, Lim SM, Cho SK, Kim JH, Song SK
- KMID: 2200601
- J Korean Soc Endocrinol.
- 2005 Oct;20(5):519-523.
- doi: 10.3803/jkes.2005.20.5.519
Methimazole is a widely used and generally well-tolerated antithyroid agent. Adverse reactions occur in 1~5% of patients taking methimazole medication, but these are most commonly transient, benign leukopenia and a... -
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- A Case of Aplasia Cutis Congenita after Methimazole Exposure during Pregnancy
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Park G, Kim HJ, Jang HC, Chung H
- KMID: 2249015
- Korean J Dermatol.
- 2006 May;44(5):642-644.
Aplasia cutis congenita is a rare congenital defect in which localized or widespread areas of the skin are singly or multiply absent or already scarred at birth. Multiple etiologies have... -
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- RE: Novel Application of Quantitative Single-Photon Emission Computed Tomography/Computed Tomography to Predict Early Response to Methimazole in Graves' Disease
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Zhang W, Huang ZQ, Lin WL, Yang SH
- KMID: 2425125
- Korean J Radiol.
- 2018 Feb;19(1):185-186.
- doi: 10.3348/kjr.2018.19.1.185
No abstract available. -
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- Acute Onset Methimazole-Induced Arthralgia and Skin Rash
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Park KH, Kim JH, Han SE, Park CS, Nam-Goong , Kim YI, Kim ES
- KMID: 2325296
- J Korean Thyroid Assoc.
- 2014 May;7(1):83-87.
Methimazole, a type of thionamide, is used to treat hyperthyroidism. Several adverse effects of thionamides have been reported. The representative minor adverse effects are arthralgia, skin rash, and gastric intolerance.... -
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- A Case of Methimazole-induced Pancytopenia: Successful Treatment with Recombinant Human Granulocyte Colony-stimulating Factor
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Lee JH, Lee J, Sung SH, Bae SH, Kim SG, Oh HK
- KMID: 2391910
- J Korean Endocr Soc.
- 2006 Dec;21(6):548-551.
Methimazole has remained the cornerstone for the treatment of hyperthyroidism since 1940's and it is a well-tolerated antithyroid drug. Pancytopenia is one of the major side effects of methimazole, but... -
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- A Case of Antithyroid Drug-Induced Agranulocytosis Treated with Granulocyte Colony-Stimulating Factor (G-CSF) and Methylprednisolone
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Eom TH, Jeoun HJ, Cho SM, Jung MH, Suh BK, Lee BC
- KMID: 1568605
- J Korean Soc Pediatr Endocrinol.
- 2004 Jun;9(1):81-85.
Although rare, agranulocytosis is the most serious, potentially fatal side effect of antithyroid drug. We experienced a 13-year-old girl who developed methimazole-induced agranulocytosis at 1 month after the initiation of... -
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- A Case Report of Methimazole-Induced Acute Liver Failure Successfully Treated with Liver Transplantation
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Jeon SJ, Kim TY, Lee SH, Kang JS, Choi GH, Lee SG, Hwang HS
- KMID: 2263459
- Korean J Med.
- 2012 Sep;83(3):363-368.
Antithyroid drugs inhibit the synthesis and excretion of thyroid hormone from the thyroid gland. Propylthiouracil (PTU) and methimazole are well known as antithyroid drugs. In 2011, the American Thyroid Association... -
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- Ensulin Autoimmune Syndrome in a Patient with Methimazole-Treated Graves' Disease: A Case report
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Lim JK, Woo YA, Kang SJ, Yoo SS, Hong KY, Kim SH
- KMID: 1944219
- J Korean Soc Endocrinol.
- 1998 Dec;13(4):612-616.
Insulin autoimmune syndrome (IAS) includes fasting or reactive hypoglycemia, hyperinsulinemia and the presence of insulin-binding antibodies in patients who have never been exposed to exogenous insulin. This report concems a... -
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- A Case of Acute Liver Failure Associated with Methimazole in Patient with Underlying Liver Disease
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Lee JE, Kim YA, Kim LK, Park YJ
- KMID: 2317756
- Soonchunhyang Med Sci.
- 2014 Dec;20(2):195-200.
- doi: 10.0000/sms.2014.20.2.195
We report a case of methimazole-induced acute hepatic failure, which occurred 4 days after initiation of drug in a 51-year-old man with hyperthyroidism. Liver function was evaluated before taking methimazole,... -
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- Methimazole-Induced Acute Cholestatic Hepatitis in a Patient with History of Simvastatin-Induced Liver Injury
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Kwak MK, Kim SR, Park JW, Han SJ, Kim MJ, Jin SY, Kim HJ, Jang JY, Byun DW, Park HK
- KMID: 2317748
- Soonchunhyang Med Sci.
- 2014 Dec;20(2):163-167.
- doi: 10.0000/sms.2014.20.2.163
Methimazole and prophylthiouracil are commonly prescribed for patients with hyperthyroidism. The serious side effect of toxic hepatitis caused by these two drugs is well known. According to recent Korean and... -
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- A Case of Methimazole-Induced Cholestatic Jaundice with Steroid Therapy
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Kim WS, Kim JH, Yoon BO, Kim YM, Song SH, Oh MJ, Hwang HG, Kim CH, Byun DW, Suh KI, Yoo MH
- KMID: 2199517
- J Korean Soc Endocrinol.
- 1999 Sep;14(3):592-598.
Cholestatic jaundice caused by imidazole derivatives is a rare complication of antithyroid drug therapy. We present a case of cholestatic jaundice with systemic hypersensitivity reaction, which developed in a 27-year... -
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- A Case of Similar Pattern of Hepatotoxicity after Propylthiouracil and Methimazole
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Lee SO, Choi JK, Kim HS, Seo JS, Ahn DS
- KMID: 2241325
- Korean J Hepatol.
- 1999 Jun;5(2):136-141.
A 46-year-old male patient developed jaundice after 23 days' treatment of propylthiouracil (PTU) for Graves' disease. Serum alkaline phosphatase was elevated markedly with moderate increase in serum aminotransferase, and the peak level... -
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- Cytoplasmic Anti-Neutrophil Cytoplasmic Antibody Positive Diffuse Alveolar Hemorrhage Associated with Methimazole
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Ryu HS, Park JH, Sheen SS, Kim TH, Han SD, Jung JY, Suh CH, Hwang SC
- KMID: 2389065
- J Rheum Dis.
- 2017 Aug;24(4):236-240.
- doi: 10.4078/jrd.2017.24.4.236
Diffuse alveolar hemorrhage (DAH) is a life-threatening condition associated with many disorders. Here, we report a case of 59-year-old female who had diffuse alveolar hemorrhage associated with methimazole. She had... -
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- Two Cases of Methimazole-Induced Insulin Autoimmune Syndrome in Graves' Disease
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Roh E, Kim YA, Ku EJ, Bae JH, Kim HM, Cho YM, Park YJ, Park KS, Kim SY, Kwak SH
- KMID: 1805947
- Endocrinol Metab.
- 2013 Mar;28(1):55-60.
- doi: 10.3803/EnM.2013.28.1.55
We report here the cases of two females with Graves' disease who developed insulin autoimmune syndrome after treatment with methimazole. The patients exhibited a sudden altered mental state after treatment... -
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- Case of Raynaud Syndrome after the Use of Methimazole
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Kim Y, Tag HS, Kim GT, Lee SG, Park EK, Park JH, Kweon SM, Yang SI, Kim JH
- KMID: 2415609
- J Rheum Dis.
- 2018 Jul;25(3):203-206.
- doi: 10.4078/jrd.2018.25.3.203
Raynaud syndrome is a medical condition that causes pain, numbness, and changes in skin color at the distal extremities. Raynaud syndrome can be subdivided into primary Raynaud's and secondary Raynaud's.... -
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- Aplasia Cutis Congenita in a Baby born to Hyperthyroid Mother Treated with Methimazole During Pregnancy: A Case Report
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Kim MJ, Kim MJ, Cho GR, Chueh HW, Jung JA, Lee YS, Kim YH, Yoo JH
- KMID: 2321963
- J Korean Soc Pediatr Endocrinol.
- 2008 Jun;13(1):100-103.
Aplasia cutis congenita is a rare congenital anomaly characterized by focal absence of skin at birth. It most commonly manifests as a solitary defect on the scalp, but sometimes it... -
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- A Case of Acute Appendicitis in a Patient with Methimazole-Induced Agranulocytosis
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Hong AR, Park KS, Jo YS, Park DJ, Park YJ, Kim JH
- KMID: 2268500
- Korean J Med.
- 2014 Feb;86(2):232-236.
Agranulocytosis is a rare, but life-threatening, adverse effect of methimazole, which usually manifests as an upper respiratory infection. Agranulocytosis together with acute appendicitis is especially rare in patients with Graves'... -
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- A Case of Methimazole-Resistant Severe Graves' Disease: Dramatic Response to Cholestyramine
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Chae SB, Kim ES, Lee YI, Min BR
- KMID: 2362357
- Int J Thyroidol.
- 2016 Nov;9(2):190-194.
- doi: 10.11106/ijt.2016.9.2.190
A 22-year-old woman with severe Graves' disease was referred from a local clinic because of her refractory hyperthyroidism. She presented with exophthalmos, diffuse goiter, and tachycardia. She was treated with... -
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- A Case of Agranulocytosis and Soft Tissue Abscess after Increasing Methimazole Dose in a Patient with Graves Disease under Long-term Mainternance Therapy
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Park SY, Chun SW, Kim YJ, Kim SJ
- KMID: 2012972
- J Korean Thyroid Assoc.
- 2011 May;4(1):54-57.
Antithyroid drugs (ATD) has been widely used to treat Graves' disease. However agranulocytosis, a serious fatal complication of ATD treatment, occurs in about 0.5 percent. The symptoms may mimic viral... -
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- Anti-tuberculosis Treatment-Induced Insulin Autoimmune Syndrome
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Han JS, Moon HJ, Kim JS, Kim HI, Kim CH, Kim MJ
- KMID: 2356384
- Ewha Med J.
- 2016 Oct;39(4):122-124.
- doi: 10.12771/emj.2016.39.4.122
Insulin autoimmune syndrome, a rare cause of endogenous hyperinsulinemic hypoglycemia, is characterized by insulin autoantibody, hyperinsulinemia and fasting hypoglycemia. It is well known that drugs containing a sulfhydryl group such... -
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