Korean J Med.
2012 Nov;83(5):624-628.
Granular Cell Tumor Originating from Gallbladder
- Affiliations
-
- 1Department of Internal Medicine, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea. 93cool@hanmail.net
- 2Department of Pathology, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.
- 3Department of Radiology, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.
Abstract
- Granular cell tumors are rare benign tumors that arise from Schwann cells. They are especially rare in the gallbladder; indeed, only four cases have been reported in the English-language literature. This paper reports a granular cell tumor in the gallbladder and is the first such report in a Korean woman. She was admitted to the hospital with jaundice and fever and was diagnosed with acute hepatitis A. While hospitalized, a well-demarcated round mass was incidentally found in her gallbladder. The acute hepatitis A improved with conservative care, but the mass did not change in size after 4 months. The tumor was resected with the gallbladder during laparoscopic surgery, and was found to be a granular cell tumor. The tumor was composed of sheets or irregular fascicles of large polygonal or spindle cells with plump eosinophilic granular cytoplasm that was immunohistochemically positive for S-100 and neuron-specific enolase and negative for neurofilament.
