Allergy Asthma Respir Dis.  2013 Dec;1(4):339-343. 10.4168/aard.2013.1.4.339.

Characteristics between IgE mediated and non-IgE mediated atopic dermatitis in children

• Kim HS
• Jung JI
• Suh SB
• Jung JA

• KMID: 2262591
• DOI: http://doi.org/10.4168/aard.2013.1.4.339

Abstract

PURPOSE
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with a association of genetic, environmental, and immunologic factors in the development of AD. And AD can be classified into IgE mediated and non-IgE mediated. We investigated a difference of clinical characteristics and immune response between the two groups.
METHODS
From January 2008 to December 2011, we enrolled 125 children who visited Dong-A University Medical Center and Busan Medical Center, and were diagnosed as AD with the Haniffin and Rajka's criteria. We checked the history of combined asthma and allergic rhinitis and allergic disease of family in patients. We measured serum total IgE, specific IgE by ImmunoCAP or skin prick test. We measured serum interleukin (IL) 4 (IL-4), interferon-gamma (IFN-gamma), IL-10, and IL-17, which are associated with chronic inflammatory disorder by flow cytometry method (Luminex).
RESULTS
Eighty (64%) were included in the IgE mediated group, while forty-five (36%) were included in the non-IgE mediated group. The frequency of combined allergic disorder and serum total eosinophil count were relatively higher in IgE mediated group (P=0.023, P=0.032). The incidence of a family history in allergic disease and the mean of SCORing Atopic Dermatitis index had no difference between the two groups. Serum IL-4, IFN-gamma, IL-10, IL-17 were higher in the IgE mediated group, but there were no statistically significant differences between two groups (P>0.05).
CONCLUSION
IgE mediated AD showed higher total eosinophil count and higher incidence of bronchial asthma and allergic rhinitis than non IgE mediated AD.

Keyword

Atopic dermatitis; Immunoglobulin E; IL-4; IFN-gamma; IL-10; IL-17

MeSH Terms

Academic Medical Centers
Asthma
Busan
Child*
Dermatitis, Atopic*
Eosinophils
Flow Cytometry
Humans
Immunoglobulin E*
Immunologic Factors
Incidence
Interferon-gamma
Interleukin-10
Interleukin-17
Interleukin-4
Interleukins
Methods
Rhinitis
Skin
Immunoglobulin E
Immunologic Factors
Interferon-gamma
Interleukin-10
Interleukin-17
Interleukin-4
Interleukins

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