Allergy Asthma Respir Dis.  2014 Jul;2(3):179-186. 10.4168/aard.2014.2.3.179.

Risk factors influencing bronchial hyperresponsiveness to methacholine in school age and adolescence of atopic dermatitis

• Sung MS
• Choi JW
• Hwang YJ
• Kim SW

• KMID: 2262517
• DOI: http://doi.org/10.4168/aard.2014.2.3.179

Abstract

PURPOSE
Many studies have shown the importance for bronchial hyperresponsiveness (BHR) in children with bronchial asthma and allergic rhinitis. However, studies have not been done in BHR in school age and adolescence with atopic dermatitis (AD).
METHODS
The patients with history of bronchial asthma were excluded and methacholine challenge test (MCT) was performed in 103 children with atopic dermatitis. The positive of MCT result is defined as provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second (PC20)< or =8 mg/mL. According of the level of PC20, the patients were divided into two groups.
RESULTS
The group 1 (BHR+) was observed in 43 of all patients (41.7%). Of two groups, significant differences were observed in age, body mass index. No significant differences were observed in the number of male, SCORing Atopic Dermatitis (SCORAD) index, admission history, smoking exposure history, other allergic disease, parental allergic disease. The group 1 (BHR+) have higher levels of total eosinophil count compared with the group 2 (BHR-) (629.8+/-360.5/microL vs. 470.2+/-253.9/microL, P=0.01). But no significant association was found between severity of BHR and SCORAD score, total immunoglobulin E, total eosin ophil count and eosinophil cationic protein (r=0.008, P=0.961; r=-0.217, P=0.162; r=0.225, P=0.147; r=-0.032, P=0.841). The list of allergen is that the house dust mite, tree, weed, food, animal hair, and fungus. The house dust mite has correlation with bronchial hypersensitivity statistically and the any of allergen groups, either.
CONCLUSION
No significant relationship was observed between degree of BHR and allergy laboratory finding, severity of AD.

Keyword

Bronchial hyperreactivity; Methacholine challenge test; Atopic dermatitis

MeSH Terms

Adolescent*
Animals
Asthma
Body Mass Index
Bronchial Hyperreactivity
Child
Dermatitis, Atopic*
Eosine Yellowish-(YS)
Eosinophil Cationic Protein
Eosinophils
Forced Expiratory Volume
Fungi
Hair
Humans
Hypersensitivity
Immunoglobulin E
Immunoglobulins
Male
Methacholine Chloride*
Parents
Pyroglyphidae
Rhinitis
Risk Factors*
Smoke
Smoking
Eosine Yellowish-(YS)
Eosinophil Cationic Protein
Immunoglobulin E
Immunoglobulins
Methacholine Chloride
Smoke

Figure

• 

  Fig. 1 Correlation of PC20 levels with total immunoglobulin E (IgE) (A), eosinophil cationic protein (ECP) (B), total eosinophil count (C), SCORing Atopic Dermatitis (SCORAD) index (D). P<0.05 is statistically significant. PC20, provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second.

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