Korean J Med.  2010 Oct;79(4):438-442.

Sirolimus-induced pneumonitis in a renal transplant recipient

Affiliations
  • 1Department of Internal Medicine, The Catholic University of College of Medicine, Seoul, Korea. yangch@catholic.ac.kr

Abstract

Sirolimus is a promising immunosuppressive agent with low nephrotoxicity and anti-tumor effects; it replaces calcineurin inhibitors, but serious adverse effects have been reported. We report on sirolimus-induced pneumonitis, which is a rare but fatal complication. The patient was a 51-year-old renal transplant recipient who had received sirolimus for 3 months before admission. The patient had a productive cough and mild fever, which began 3 weeks before admission. The chest PA and CT findings were consistent with pneumonia, but a microbiological study and bronchoscopic findings revealed no evidence of infection. Sirolimus-induced pneumonitis was suspected, so the sirolimus was stopped and high-dose steroids were initiated. The respiratory symptoms and radiologic findings improved dramatically after sirolimus withdrawal and the initiation of steroid treatment. These findings strongly suggest a casual relationship between sirolimus and pneumonitis. This is the first case of sirolimus-induced pneumonitis in Korea.

Keyword

Sirolimus; Renal transplant; Pneumonitis

MeSH Terms

Calcineurin
Cough
Fever
Humans
Korea
Middle Aged
Pneumonia
Sirolimus
Steroids
Thorax
Transplants
Calcineurin
Sirolimus
Steroids
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