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Spatiotemporal expression of RCAN1 and its isoform RCAN1-4 in the mouse hippocampus after pilocarpine-induced status epilepticus

Cho KO, Jeong KH, Cha JH, Kim SY

Regulator of calcineurin 1 (RCAN1) can be induced by an intracellular calcium increase and oxidative stress, which are characteristic features of temporal lobe epilepsy. Thus, we investigated the spatiotemporal expression...
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Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report

Kim Y, Kim DI, Shim JR, Lee TB, Yang KH, Ryu JH, Lee HJ, Choi BH

Pancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial. In...
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Linear Lichen Planopilaris of the Face Successfully Treated with Topical Calcineurin Inhibitor

Seo HM, Lee H, Bang CH, Lee JH, Park YM, Lee JY

  • KMID: 2457699
  • Korean J Dermatol.
  • 2019 Aug;57(7):412-413.
No abstract available.
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The Korean Organ Transplant Registry (KOTRY): Second Official Adult Heart Transplant Report

Kim D, Choi JO, Oh J, Cho HJ, Jung SH, Lee HY, Kang SM, Kim JJ, Jeon ES

BACKGROUND AND OBJECTIVES: This second adult heart transplantation (HTx) report is based on Korean Organ Transplant Registry data submitted on 400 HTxs in recipients of all ages. METHODS: From March 2014...
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Efficacy and Utility of Wet Wrap Dressing for Patients with Pediatric Atopic Dermatitis

Choi JW, Loh SH, Lew BL, Sim WY

  • KMID: 2454369
  • Korean J Dermatol.
  • 2019 Jul;57(6):301-306.
BACKGROUND: Management of atopic dermatitis (AD) involves the regular use of emollients together with topical steroids or calcineurin inhibitors for acute flares. However, the long-term use of oral medications in...
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Impact of calcineurin inhibitors on rat glioma cells viability

Seong JH, Park WY, Paek JH, Park SB, Han S, Mun KC, Jin K

BACKGROUND: Although kidney transplantation outcomes have improved dramatically after using calcineurin inhibitors (CNIs), CNI toxicity continues to be reported and the mechanism remains uncertain. Here, we investigated the neurotoxicity of...
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Comparison of Transplant Outcomes for Low-level and Standard-level Tacrolimus at Different Time Points after Kidney Transplantation

Jung HY, Cho SY, Choi JY, Cho JH, Park SH, Kim YL, Kim HK, Huh S, Won DI, Kim CD

BACKGROUND: Optimal tacrolimus (TAC) trough levels for different periods after kidney transplantation (KT) has not been definitely established. This study aimed to investigate transplant outcomes of low-level (LL) and standard-level...
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Current new challenges in the management of ulcerative colitis

Fukuda T, Naganuma M, Kanai T

Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract. Although the cause of UC is postulated to be multifactorial in nature, including genetic predisposition, epithelial barrier defects,...
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Treatment of Atopic Dermatitis

Han TY, Na CH, Lee JH, Kim HO, Park CO, Seo YJ, Son SW, Shin MK, Ahn JY, Lee YW, Jang YH, Park YL, Lew BL

  • KMID: 2437050
  • Korean J Dermatol.
  • 2018 Dec;56(10):581-593.
Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that affects both children and adults. AD is the cause of considerable morbidity including severe pruritus and impaired quality...
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A clinician's reference guide for the management of atopic dermatitis in Asians

Chow S, Seow CS, Dizon MV, Godse K, Foong H, Chan V, Khang TH, Xiang L, Hidayat S, Listiawan , Triwahyudi D, Gondokaryono SP, Sutedja E, Diana IA, Suwarsa O, Dharmadji , Siswati AS, Danarti R, Soebaryo R, Budianti W, for the Asian Academy of Dermatology & Venereology

BACKGROUND: Atopic dermatitis (AD) is a common skin condition among Asians. Recent studies have shown that Asian AD has a unique clinical and immunologic phenotype compared with European/American AD. OBJECTIVE: The...
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A Clinical and Etiological Analysis of Tinea Incognito Over 10 Years: A Single-Center Experience

Park MW, Suh MK, Ha GY

BACKGROUND: Tinea incognito is the dermatophytoses of atypical clinical appearance that is induced by topical and systemic steroid treatment or topical calcineurin inhibitor. OBJECTIVE: The purpose of this study was to...
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Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

Xu P, Chen J, Tan C, Lai RS, Min ZS

Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle...
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Allergic conjunctivitis in Asia

Thong BY

Allergic conjunctivitis (AC), which may be acute or chronic, is associated with rhinitis in 30%–70% of affected individuals, hence the term allergic rhinoconjunctivitis (AR/C). Seasonal and perennial AC is generally...
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Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors

Kocahan S, DoÄŸan Z

The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment, neuronal death and the loss of synapses, all...
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Calcineurin Inhibitor Induced Multiple Infarctions

Jeong HB, Kim JM, Yu IH, Bae JH, Kwon OS, Park KY

Tacrolimus is the most commonly used immunosuppressant after kidney transplantation. Here, we report a patient with multiple cerebral infarctions during tacrolimus treatment after kidney transplantation. A 54-year-old female was admitted...
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Sirolimus Combination with Tacrolimus in Kidney Transplant Recipients at High Immunological Risk: Observational Results 3 Years after Transplantation

Lee J, Song SH, Lee JG, Kim BS, Huh KH, Kim YS

BACKGROUND: The optimal immunosuppressive strategy for renal transplant recipients at high immunological risk requires clarification. We compared the 3 year outcomes of a sirolimus group (tacrolimus plus sirolimus) to those...
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Successful Balloon Angioplasty with Low-pressure Balloon on Early Transplant Renal Artery Stenosis at Postoperative Day 7

Kim DY, Jung HD, Lee JH, Kim HS, Lee DY, Oh JS, Kim SM, Sin YH, Kim JK, Huh K, Park JH, Jung GS

Transplant renal artery stenosis (TRAS) is an important cause of hypertension, allograft dysfunction, and graft loss. Patient and allograft survival rates are lower in patients with TRAS. Causes of TRAS...
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A Comprehensive Review of the Treatment of Atopic Eczema

Lee JH, Son SW, Cho SH

Atopic eczema (AE) is a chronic, inflammatory skin disorder which usually develops in early childhood. In spite of intensive investigations, the causes of AE remain unclear, but are likely to...
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A Case of Refractory Vitiligo That Was Treated with a Combination of Non-ablative 1550-nm Erbium:Glass Fractional Laser, Narrow-band UVB, and a Topical Agent

Park JB, Park JH, Chun SH, Jang HW, Ryu HJ, Kim IH

  • KMID: 2251147
  • Korean J Dermatol.
  • 2016 May;54(4):280-283.
There are many therapeutic methods for treating vitiligo, including narrow-band UVB, topical corticosteroids, calcineurin inhibitors, excimer laser, and surgical methods, such as autologous epidermal grafting and dermabrasion. However, although various...
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Safety and immunologic benefits of conversion to sirolimus in kidney transplant recipients with long-term exposure to calcineurin inhibitors

Yu JH, Kim KW, Kim BM, Chung BH, Cho ML, Choi BS, Park CW, Kim YS, Yang CW

BACKGROUND/AIMS: Sirolimus (SRL) is a promising immunosuppressant replacingcalcineurin inhibitors (CNIs). This study was performed to evaluate the safetyand immunologic benefits of conversion to SRL in stable kidney transplant (KT)recipients exposed...
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