Korean J Med.  2011 Jun;80(6):723-728.

A Case of Bilateral Acute Renal Cortical Necrosis Complicated by Tranexamic Acid Administration

• Park JH
• Kang MK
• Na WT
• Song IG
• Jung JH
• Yoon SH
• Yun SR

Abstract

Acute renal cortical necrosis is an anuric form of acute renal failure. We experienced a case of renal cortical necrosis complicated by tranexamic acid administration. To our knowledge, only three cases of renal cortical necrosis have been reported worldwide. A 49-year-old man was referred with hemothorax and multiple bone fractures following a traffic accident. Tranexamic acid, and hemocoagulase were injected three times a day. After the 4th dose of hemostatics, anuria developed abruptly, the platelet count decreased to 84,000 /microL, and the serum creatinine was increased to 2.56 from 1.06 mg/dL. On the 4th Intensive Care Unit (ICU) day, computed tomography (CT) showed bilateral renal cortical necrosis with normal renal arteries and aorta. The oliguria persisted for 14 days and temporary hemodialysis was performed. The serum creatinine had decreased to 2.12 mg/dL 8 months after discharge.

Keyword

Kidney cortex necrosis; Tranexamic acid; Acute kidney failure; Anuria

MeSH Terms

Accidents, Traffic
Acute Kidney Injury
Anuria
Aorta
Batroxobin
Creatinine
Fractures, Bone
Hemostatics
Hemothorax
Humans
Intensive Care Units
Kidney Cortex Necrosis
Middle Aged
Oliguria
Platelet Count
Renal Artery
Renal Dialysis
Tranexamic Acid
Batroxobin
Creatinine
Hemostatics
Tranexamic Acid