Korean J Neurogastroenterol Motil.  2006 Jun;12(1):31-34.

The Effect of Tadalafil on Gastric Emptying of Healthy Adults

• Kim MS
• Chang JH
• Kim ES
• Hwang SJ
• Jahng JH
• Kim SM
• Ryu YH
• Park HJ

Abstract

BACKGROUND/AIMS: In a previous study we demonstrated an influence of sildenafil, a phosphodiesterase (PDE) type 5 inhibitor, on intragastric food maldistribution without affecting total gastric emptying. In this we wanted to determine the effect of tadalafil (cialis?), which has longer duration of action than sildenafil, on gastric emptying.
METHODS
Eight male (mean age, 26.4 yrs) healthy volunteers were selected. Total T1/2 (min) was measured to assess total gastric emptying before, 30 minutes and 24 hours after tadalafil intake. Proximal T1/2 (min), initial proximal activity (%)-radioactiviy measured in the proximal body of the stomach immediately after food ingestion-, and the maximal distal content (%)-the highest radioactiviy measured in the distal body of the stomach was measured as indicators of intragastric food distribution.
RESULTS
There were no significant differences in total T1/2 (min), proximal T1/2 (min), initial proximal activity (%) and maximal distal content (%) before and 30 minutes and 24 hrs after intake of tadalafil.
CONCLUSIONS
The recently launched PDE5 inhibitor, tadalafil, has no significant influence on total gastric emptying or intragastric food distribution.

Keyword

Phosphodiesterase type 5 inhibitor; Gastric emptying; Intragastric food distribution; Tadalafil

MeSH Terms

Adult*
Gastric Emptying*
Healthy Volunteers
Humans
Male
Stomach
Tadalafil
Sildenafil Citrate