The Effect and Mechanics of the Resin on Gastric Emptying Scintigraphy

Hyun, Jin Hai; song, Chi Wook; Ryu, Ho Sang; Park, Hyun Chul; Choe, Jae Gol

Abstract

Backgrouad/Aims: Gastric emptying scintigraphy is known as an effeetive method for the measurement of gastric functions. There are, however, few methodological investigations about the effect and mecbanism of the resin (arnberlite, RIA-410) on gastric emptying time (GET). The aims of this study were to evaluate the effect of resin on GET and to study its mechanism.
METHODS
For human study, we performed gastric emptying scintigraphy twice for each of 28 healthy volunteets. For the first scintigraphy, we fed them the test meal mixed with the labeled resin (resin (+) group) and then the same meal without the resin one week later (resin (-) group). In vitro study, we mixed three different fluids with the same test meal used for the above human studies and then separated them into two parts, fluid and solid components, by the centrifuge. We measured percentage of free technetium within the liquid cornponent.
RESULTS
The GET T1/2 values in resin (+) group were significantly longer than those in resin (-) group (p<0.001). Two hour retention rates in the resin (+) group (38.3+/-13.0%) were significantly higher than those in the resin (-) group (25.3+/-12.3%)(P<0.001). The resin (-) meals showed a higher percentage of free technetium in the liquid than the resin (+) meals.
CONCLUSIONS
In the resin (-) group, the gastric emptying time was shorter and the percentage of free technetium was higher than in the resin (+) group. These results suggest that the rapid gastric ernptying in the resin (-) group is probably due to rapid emptying of unbound technetium along with liquid component of the meal.