Gastric Emptying Time in CAPD Patients

Kang, J Y; Moon, K H; Song, I S; Ryu, J S; Lee, J S; Lee, S K

Abstract

This study was performed to evaluate the prevalence of increased gastric emptying time(GET) and the relationship between GET and nutritional status in CAPD patients. GET using 99mTc-DTPA labeled egg fry was measured in 72 CAPD patients(45 M, 27 F, age 28-76yr, median 57) and 29 predialysis CRF patients(15 M, 14 F, age 29-75yr, median 52) and 17 healthy volunteers(9 M, 8 F, age 28-68yr, median 43). Nutritional markers were measured in CAPD patients. In control group, GET was 57+/-9minutes(mean+/-S.D.). The prevalence of diabetes between CAPD and CRF patients was not different(54% vs. 62%). In CAPD patients, increased GET(>75 min; mean+2S.D.) was more prevalent than in CRF patients(53% and 28%, P<0.05). In diabetic CAPD patients, GET was more increased than that in non-diabetic CAPD patients (64% and 39%, P<0.05). Albumin and IGF-1 are lower in non-diabetic CAPD patients with increased GET than those in the patients with normal GET. Albumin and prealbumin are lower in diabetic CAPD patients with increased GET than those in the patients with normal GET. There was no difference in triceps skin fold, mid arm muscle area, Kt/V, PCR, insulin-like growth factor-1, cholesterol and transferrin. Symptom severity scores were checked in 19 of 38 CAPD patients with increased GET. Only 8 of 19 patients experienced gastrointestinal symptoms. This study suggest that GET is increased in more than half of CAPD patients, and the prevalence of increased GET are higher in CAPD patients than that in CRF patients. Increased GET may contribute to malnutrition in CAPD patients.