Korean J Nephrol.  2005 May;24(3):494-500.

A Case of Pure Red Cell Aplasia Due to Parvovirus B19 Infection in a Renal Transplant Recipient

• Oh HJ
• Cheon JW
• Ahn DJ
• Kim SG
• Ahn KS
• Lee IH

Abstract

We report a case of pure red cell aplasia due to parvovirus B19 infection in a renal transplant recipient. The patient was a 32-year-old male with end stage renal disease due to chronic glomerulonephritis, who had been undergoing regular hemodialysis. He received a living nonrelated renal transplant and immumosuppressive therapy including prednisolone, tacrolimus, and mycophenolate mofetil. One week after kidney transplantation, severe anemia was persisted despite recombinant human erythropoietin administration and packed red blood cell transfusion. His bone marrow aspiration smear demonstrated erythroid hypoplasia and giant pronormoblasts with prominent intranuclear inclusions. Both serum and bone marrow were positive for parvovirus B19 DNA polymerase chain reaction and anti-parvovirus B19 IgM. He was treated with intravenous immunoglobulin and conversion of tacrolimus to cyclosporine. His hemoglobin level was completely recovered three months later.

Keyword

Pure red cell aplasia; Parvovirus B19; Kidney transplantation

MeSH Terms

Adult
Anemia
Bone Marrow
Cyclosporine
DNA
Erythroblasts
Erythrocyte Transfusion
Erythropoietin
Glomerulonephritis
Humans
Immunoglobulin M
Immunoglobulins
Intranuclear Inclusion Bodies
Kidney Failure, Chronic
Kidney Transplantation
Male
Parvovirus*
Polymerase Chain Reaction
Prednisolone
Red-Cell Aplasia, Pure*
Renal Dialysis
Tacrolimus
Transplantation*
Cyclosporine
DNA
Erythropoietin
Immunoglobulin M
Immunoglobulins
Prednisolone
Tacrolimus