Korean J Med.  2004 Jul;67(1):49-57.

Effects of bovine colostrum in diclofenac induced gut injured rat model

• Kim JW
• Jeon WK
• Chun HB
• Kim YC
• Yun JW
• Park DI
• Cho YK
• Sung IK
• Park CY
• Sohn CI
• Kim BI
• Yeon JS
• Park HS
• Sohn JH
• Kim EJ
• Shin MS
• Lee DH

Abstract

BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medicine but induce damage throughout the entire gastrointestinal tract including small intestine with protein and blood loss. Impaired epithelial barrier function, overgrowth of luminal bacteria and others have been implicated in the pathogenesis of NSAID induced enteropathy. Colostrum is a first milk produced after birth and is particularly rich in growth factors, immunoglobulins and antimicrobial peptides. The present study aimed to exam whether defatted bovine colostrum reduce small intestinal injury caused by diclofenac in the animals.
METHODS
64 rats were utilized in four groups; control group, diclofenac group, diclofenac with 5% colostrum group and diclofenac with 10% colostrum group. The animals with colostrum were fed with 5% or 10% colostral solution for 5 days before diclofenac administration. Small intestinal injury was induced by administering a single dose of diclofenac (50 mg/kg subcutaneously). Epithelial permeability, enteric aerobic bacterial counts, serum albumin and protein levels, and pathologic findings of distal ileum were measured.
RESULTS
Diclofenac caused marked increase in intestinal permeability, enteric bacterial numbers and intestinal villous damage, and declines in serum levels of total protein and albumin. Co-administration of bovine colostrum reduced intestinal permeability and enteric bacterial numbers, declines in serum albumin and protein levels, and mucosal damage of small intestine induced by diclofenac.
CONCLUSION
Bovine colostrums may have beneficial effects on preventing NSAID induced small intestinal injury and bacterial translocation.

Keyword

Non-Steroidal Anti-Inflammatory Drugs; Intestinal Permeability; Bovine Colostrum

MeSH Terms

Animals
Bacteria
Bacterial Load
Bacterial Translocation
Colostrum*
Diclofenac*
Gastrointestinal Tract
Ileum
Immunoglobulins
Intercellular Signaling Peptides and Proteins
Intestine, Small
Milk
Models, Animal*
Parturition
Peptides
Permeability
Phenobarbital
Rats*
Serum Albumin
Diclofenac
Immunoglobulins
Intercellular Signaling Peptides and Proteins
Peptides
Phenobarbital
Serum Albumin