Korean J Urol.  2006 Oct;47(10):1111-1116. 10.4111/kju.2006.47.10.1111.

The Suppressive Effect of Bovine Colostrum Combined with Antibiotics on Renal Inflammation

• Park JK
• Park HJ
• Joo KJ

• KMID: 2139815
• DOI: http://doi.org/10.4111/kju.2006.47.10.1111

Abstract

PURPOSE: Bovine colostrum contains three times more immunoglobulin than human colostrums does. We investigated the effectiveness of administering Bovine colostrum combined with antibiotics in an animal model of ascending pyelonephritis.
MATERIALS AND METHODS
Thirty female Sprague-Dawley rats were divided into 5 groups: the normal group, the non-treated control group, the Bovine colostrum administered group, the antibiotic treatment group and the combined administration of antibiotics and Bovine colostrums group. After anesthetizing, an inoculum of 1 x 10(8) colony forming units per ml of Escherichia coli (E. coli, ATCC 25922 strain) was instilled into the bladder through the urethra and the urethra was occluded for 4 hours. We began treatment with ciprofloxacin (15mg/kg, for 5 days, intramuscularly) alone or Bovine colostrum (6ml/kg, for 5 days, orally) alone or with combination treatment 72 hours after inoculation. The rats were sacrificed 4 weeks after infection. Both kidneys were examined pathologically. We carried bacterial culture examinations of the urine and the kidney tissue.
RESULTS
As the results of examining the cultures of the urine and kidney tissues, no bacteria were cultivated in the antibiotics treatment group and the combined treatment group. 66.7% of the control group and 33.3% of the bovine colostrum treatment group had positive urine cultures and 66.7% of the control group and 41.7% of the bovine colostrum treatment group showed a positive reaction on the kidney tissue culture. The severity of pyelonephritis, as noted on the pathological examination, was highest in the control group. The combined treatment group had the lowest degree of infection among all the groups.
CONCLUSIONS
The administration of bovine colostrum in combination with antibiotics can significantly reduce the inflammation associated with ascending pyelonephritis.

Keyword

Colostrum; Pyelonephritis; Inflammation

MeSH Terms

Animals
Anti-Bacterial Agents*
Bacteria
Ciprofloxacin
Colostrum*
Escherichia coli
Female
Humans
Immunoglobulins
Inflammation*
Kidney
Models, Animal
Pyelonephritis
Rats
Rats, Sprague-Dawley
Stem Cells
Urethra
Urinary Bladder
Anti-Bacterial Agents
Ciprofloxacin
Immunoglobulins

Figure

• 

  Fig. 1 Grade of inflammation of each group. The degree of inflammation is lowest for the combined treatment group.

• 

  Fig. 2 Light microscopic findings of the renal prenchyma 4 weeks after infection. The control group (A) and the bovine colostrum treatment group (B). Marked inflammation of the renal parenchyma is seen at both group. Yet the inflammation of the bovine colostrum treatment group is less severe than that of the bovine colostrum treatment group (H&E, ×100).

• 

  Fig. 3 Light microscopic findings of the renal prenchyma 4 weeks after infection. The antibiotic treatment group (A) and the combined treatment group (B). The area of inflammation of the combined treatment group is much smaller than that of the antibiotic treatment group (H&E, ×100).

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