J Korean Surg Soc.  2006 Jun;70(6):462-469.

The Effect of Preoperative Oral Application of Bovine Colostrum on Endotoxemia and TNF-alpha in Abdominal Surgery

• Seo HI
• Jeon WK
• Kang JH
• Lim SY
• Lee SS
• Sohn BH
• Ryu CH
• Shin JH
• Kim HD
• Han WK
• Oh TY
• Woo HY
• Park HS

Abstract

PURPOSE: We conducted this study to assess the effect of oral application of bovine colostrum on the plasma endotoxin and TNF-alpha following the abdominal surgery.
METHODS
46 patients who underwent the abdominal surgery were evenly enrolled in a prospective, randomized, double blind and placebo-controlled study. The patients were preoperatively managed by oral application of 20 g of a bovine colostrums or placebo (nonfat dried milk) per a day for 3 days. In both groups, endotoxin was sequentially determined pre-, intra- and postoperatively by a modified limulus amebocyte lysate test. TNF-alpha and CRP were also measured. The clinical course was followed and compared in both groups.
RESULTS
The colostrum group showed significantly lower level of endotoxin and TNF-alpha compared to the placebo group. CRP did not differ in both groups. Clinical event did not occur in both group until the discharge. Colostrum group tends to have a lower incidence of fever and leukocytosis without statistic significance.
CONCLUSION
Prophylactic preoperative oral application of bovine colostrum lower the plasma level of perioperative endotoxin and TNF-alpha. Further studies were needed for the relation of clinical effect and preoperative oral application of bovine colostrum.

Keyword

Bovine colostrums; Endotoxemia; TNF-alpha; Abdominal surgery

MeSH Terms

Colostrum*
Endotoxemia*
Fever
Horseshoe Crabs
Humans
Incidence
Leukocytosis
Plasma
Prospective Studies
Tumor Necrosis Factor-alpha*
Tumor Necrosis Factor-alpha