J Vet Sci.  2001 Aug;2(2):139-141.

Cloning a new allele form of bovine TNF-alpha

• Ahn J

Abstract

Although little is known on the function of gammadelta T lymphocytes, there is increasing evidence that gammadelta T lymphocytes are early responders and modulators of immune responses against pathogens and cytokines such as IL-2, IL-7, IL-15 and TNF-alpha. To study the role TNF-alpha on gammadelta T lymphocytes, we cloned bovine TNF-alpha. Sequence analysis revealed that a new allele form of bovine TNF-alpha was cloned which has 3 additional nucleotide sequences as well as 3 nucleotide substitutions compared with previously reported bovine TNF-alpha. Further studies are needed to document the functional significance of a new allele form of TNF-alpha in cattle.

Keyword

New allele; bovine; TNF-alpha

MeSH Terms

*Alleles
Amino Acid Sequence
Animals
Base Sequence
Cattle
*Cloning, Molecular
Gene Library
Molecular Sequence Data
Receptors, Antigen, T-Cell, gamma-delta/*physiology
Sequence Alignment/veterinary
T-Lymphocytes/immunology/*physiology
Tumor Necrosis Factor-alpha/chemistry/*genetics/physiology