Korean J Med.  2006 Oct;71(4):354-361.

Protective effects of mastic in non-steroidal anti-inflammatory drug induced gut damage and bacterial translocation in a rat model

• Heo C
• Kim SW
• Kim KJ
• Kim DW
• Kim HJ
• Do JH
• Chang SK

Abstract

BACKGROUND: NSAIDs induce gut damage and bacterial translocation throughout the entire gastrointestinal tract. The aim of the present study was to examine whether mastic, a natural resinous exudate obtained from the Pistacia lentiscus treetrees, can reduce diclofenac induce gut damage and bacterial translocation in rats.
METHODS
32 SD rats were divided into four groups; a control group, diclofenac group, diclofenac with 0.3 cc/kg mastic group and diclofenac with 1.0 cc/kg mastic group. Mastic oils were administered 3 hours before diclofenac administration (100 mg/kg orally x2 days). Intestinal permeability, enteric aerobic bacterial counts in the distal ileum and cecum, intestinal adhesion, lipid peroxidation of distal ileum, and bacterial translocation to mesenteric lymph nodes, liver, spleen, kidney and heart were measured, respectively
RESULTS
Diclofenac caused marked increase in intestinal permeability, enteric bacterial numbers in distal ileum and cecum, intestinal adhesion, lipid peroxidation of the distal ileum, and bacterial translocation to mesenteric lymph nodes, liver, spleen, kidney and heart of which event were reduced with Mostic coadminist. Howere mastic oil showed significant profect effects in 1.0 cc/kg dose.
CONCLUSIONS
Mastic was proven to have beneficial effects on preventing NSAID induced gut injury and bacterial translocation in a rat model.

Keyword

Anti-Inflammatory Agents; Non-Steroidal; Adverse effects; Intestine; Bacterial translocation; Mastic

MeSH Terms

Animals
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Bacterial Load
Bacterial Translocation*
Cecum
Diclofenac
Exudates and Transudates
Gastrointestinal Tract
Heart
Ileum
Intestines
Kidney
Lipid Peroxidation
Liver
Lymph Nodes
Models, Animal*
Oils
Permeability
Pistacia
Rats*
Spleen
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Diclofenac
Oils