Korean J Hematol.  2012 Sep;47(3):225-228. 10.5045/kjh.2012.47.3.225.

A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer

Affiliations
  • 1Department of Laboratory Medicine, Gachon University Gil Medical Center, Incheon, Korea. jyahn@gilhospital.com
  • 2Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.

Abstract

Radioiodine is regularly used in the treatment of thyroid cancer to eliminate residual malignant tissue after thyroidectomy and to treat metastasis. Because of the low dose of radioiodine used to treat thyroid cancer patients, leukemia is an uncommon complication of exposure to radioiodine. Here, we present a patient who developed therapy-related acute myeloid leukemia with inv(16)(p13.1q22);CBFbeta-MYH11, eosinophilia, and K-ras mutation and who had been treated with very low-dose radioiodine following total thyroidectomy.

Keyword

Radioiodine; Thyroid cancer; Acute myeloid leukemia; CBFbeta-MYH11; Eosinophilia; K-ras

MeSH Terms

Eosinophilia
Humans
Leukemia
Leukemia, Myeloid, Acute
Neoplasm Metastasis
Oncogene Proteins, Fusion
Thyroid Gland
Thyroid Neoplasms
Thyroidectomy
Oncogene Proteins, Fusion
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