Ann Lab Med.  2021 May;41(3):333-335. 10.3343/alm.2021.41.3.333.

A Case of Acute Myeloid Leukemia With inv(16) (p13.1q22);CBFB-MYH11 Presenting With Faggot Cells

• Kim JA
• Shin WY
• Kim J
• Bang HI
• Yoon SY
• Won JH
• Park R

• KMID: 2512693
• DOI: http://doi.org/10.3343/alm.2021.41.3.333

Figure

• 

  Fig. 1 Morphology, FISH, and cytogenetics of bone marrow. (A–C) Aspirate smears (Wright-Giemsa stain; magnification, 1,000 ×) showing a variety of faggot cells. (D) FISH analysis showing CBFB-MYH11 gene rearrangement by inv(16) (white arrow). (E) Conventional cytogenetics showing 47,XX,inv(16)(p13.1q22),+22. Abbreviation: CBFB, core-binding factor subunit beta.

Reference

1. Tallman MS, Altman JK. 2009; How I treat acute promyelocytic leukemia. Blood. 114:5126–35. DOI: 10.1182/blood-2009-07-216457. PMID: 19797519.

2. Ogura H, Inagaki A, Wakita A. 2013; A case of myelodysplastic syndrome presenting with faggot-like cells. Int J Hematol. 97:443–5. DOI: 10.1007/s12185-013-1306-z. PMID: 23475771.

3. Ohnishi H, Yoshino H, Yoneyama R, Ishii M, Watanabe T, Bessho F. 2008; Faggot formation in mature neutrophils and metamyelocytes in acute myeloid leukemia without maturation. Pediatr Hematol Oncol. 25:165–70. DOI: 10.1080/08880010801937894. PMID: 18432498.

4. Jerez A, del Mar Osma M, Amigo M, Ortuño FJ. 2010; Faggot cells in an HIV-positive patient with inv(16)/therapy-related acute myeloid leukaemia. Br J Haematol. 150:646. DOI: 10.1111/j.1365-2141.2010.08294.x. PMID: 20666775.

5. Garrastazul-Sánchez MP, Vilches-Moreno M, Fernández-Valle MC, Marchante-Cepillo I, Prats-Martín C, Bernal R, et al. 2019; Neutrophil faggot cells and inv(16): not such a fortuitous association? Ann Hematol. 98:1293–5. DOI: 10.1007/s00277-018-3484-5. PMID: 30151638.

6. Kim KJ, Kim IS. 2020; Bundles of Auer rods in mature neutrophils in a pediatric acute myeloid leukemia patient with inv(16)(p13.1q22). Int J Lab Hematol. 42:e164–6. DOI: 10.1111/ijlh.13217. PMID: 32338823.

7. Gupta A, Reddy KG, Goyal M. 2018; "Faggot neutrophils!" in non-acute promyelocytic leukemia: a rare occurrence. Indian J Hematol Blood Transfus. 34:778–80. DOI: 10.1007/s12288-018-0961-x. PMID: 30369767. PMCID: PMC6186241.

8. Chang H, Kuo MC, Shih LY, Dunn P, Wang PN, Wu JH, et al. 2012; Clinical bleeding events and laboratory coagulation profiles in acute promyelocytic leukemia. Eur J Haematol. 88:321–8. DOI: 10.1111/j.1600-0609.2011.01747.x. PMID: 22221178.

9. Paschka P, Du J, Schlenk RF, Gaidzik VI, Bullinger L, Corbacioglu A, et al. 2013; Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). Blood. 121:170–7. DOI: 10.1182/blood-2012-05-431486. PMID: 23115274.