Korean J Dermatol.  2008 Jun;46(6):788-791.

Acquired Reactive Perforating Collagenosis in a Chronic HCV Hepatitis Patient Who was Treated with Interferon Alpha

• Choi YJ
• Shin MS
• Ahn JY
• Park MY

Abstract

Reactive Perforating Collagenosis (RPC) is a kind of perforating dermatosis, which shows transepidermal elimination of altered collagens. Acquired form is developed in an adult without family history, is favorably developed in scratched region due to pruritic sense. Acquired RPC has been reported to be associated with various systemic disorders, such as diabetes mellitus, liver disease, chronic renal failure, lymphoma, AIDS, hypothyroidism, hyperparathyroidism, and neurodermatitis, accompanied by itching & scratching. We report a case of acquired RPC in a patient with HCV hepatitis who was treated with interferon alpha. Skin lesions showed multiple erythematous centrally umbilicated, crusted papules of variable sizes on the extensor surfaces of both shins.

Keyword

Acquired reactive perforating collagenosis; HCV; Interferon alpha

MeSH Terms

Adult
Collagen
Diabetes Mellitus
Hepatitis
Humans
Hyperparathyroidism
Hypothyroidism
Interferon-alpha
Interferons
Kidney Failure, Chronic
Liver Diseases
Lymphoma
Neurodermatitis
Pruritus
Skin
Skin Diseases
Collagen
Interferon-alpha
Interferons