Korean J Dermatol.
2008 Nov;46(11):1513-1516.
A Case of Generalized Hyperpigmentation Caused by Antituberculosis Drugs
- Affiliations
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- 1Department of Dermatology,Wonkwang University School of Medicine, Iksan, Korea. sdpark@wku.ac.kr
- 2Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
Abstract
- Hyperpigmentation caused by medication or toxic agents accounts for 10~20% of all the cases of acquired hyperpigmentations. Nonsteroidal anti-inflammatory drugs, antimalarials, amiodarone, cytotoxic drugs, tetracyclines, heavy metals and psychotropic drugs are most commonly responsible for hyperpigmentation. A 74-year-old man who had taken antituberculosis drugs (rifampin and isoniazid) for 4 months developed generalized hyperpigmentation. The histopathologic finding revealed an increased number of dermal melanophages with pigment incontinence. Eight months after termination of the antituberculosis medication, his skin lesion improved without any treatment. To the best of our knowledge, this is the first reported case of generalized hyperpigmentation due to rifampin and isoniazid in a patient without adrenal insufficiency in the dermatological literature.
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