Korean J Dermatol.  2008 Aug;46(8):1145-1148.

A Case of Lichenoid Drug Eruption with Whole Body and Oral Mucosal Involvement Caused by Antituberculosis Drugs

• Na CH
• Seo HD
• Chung BS
• Shin BS

Abstract

Lichenoid drug eruption can arise as a result of exogenous compound exoposures and closely mimic idiopathic lichen planus. A 45-year-old man who had taken antituberculosis drugs (isoniazid, rifampin, ethambutol, pyrazinamide) for 2 months developed pruritic violaceous papules and plaques with silvery scales on the whole body. On close inspection, he had superficial erosions on the lips and reticulate white papules on the buccal mucosa. Histopathologic findings were hyperkeratosis, parakeratosis, and hypergranulosis in the epidermis and band-like lymphohistiocytic infiltration, numerous eosinophils, and perivascular lymphohistiocytic infiltration in the dermis. The skin lesions improved leaving hyperpigmentation after cessation of the antituberculosis drugs and application of topical corticosteroid.

Keyword

Antituberculosis drugs; Lichenoid drug eruption

MeSH Terms

Dermis
Drug Eruptions
Eosinophils
Epidermis
Ethambutol
Humans
Hydrazines
Hyperpigmentation
Lichen Planus
Lip
Middle Aged
Mouth Mucosa
Parakeratosis
Rifampin
Skin
Weights and Measures
Ethambutol
Hydrazines
Rifampin