Korean J Dermatol.  2008 Jan;46(1):130-133.

A Case of Lichenoid Drug Eruption Caused by Allopurinol

• Lee HS
• Han SH
• Song HJ
• Hong WK
• Shin J
• Choi GS

Abstract

Lichenoid drug eruption is a lichenoid skin eruption caused by certain drugs and compounds, and can be similar to lichen planus. A 51-year-old man who had taken antihypertensive drugs (enalapril, dilazep dihydrochloride) and cholesterol lowering drug (atorvastatin) for 4 years had received allopurinol for asymptomatic hyperuricemia for 4 months. He developed pruritic erythematous papules and plaques with silvery scales on the face, trunk and extremities after taking allopurinol for 3 months. He had no fever, no eosinophilia and no systemic abnormalities. Histopathologic findings showed hyperkeratosis, parakeratosis, hypergranulosis, band-like lymphohistiocytic infiltration and perivascular lymphohistiocytic infiltration in the dermis, which were compatible with lichenoid drug eruption. The skin rashes disappeared after he stopped taking allopurinol and was treated with steroids.

Keyword

Allopurinol; Lichenoid drug eruption

MeSH Terms

Allopurinol
Antihypertensive Agents
Cholesterol
Dermis
Dilazep
Drug Eruptions
Enalapril
Eosinophilia
Exanthema
Extremities
Fever
Humans
Hyperuricemia
Lichen Planus
Middle Aged
Parakeratosis
Skin
Steroids
Weights and Measures
Allopurinol
Antihypertensive Agents
Cholesterol
Dilazep
Enalapril
Steroids