Yeungnam Univ J Med.  1995 Dec;12(2):405-411. 10.12701/yujm.1995.12.2.405.

A Case of Lichenoid Drug Eruption Caused by Antituberculosis Drug

• Lee SK
• Choi JS
• Kim KH

• KMID: 2320389
• DOI: http://doi.org/10.12701/yujm.1995.12.2.405

Abstract

Lichenoid drug eruption is lichenoid skin eruptions caused by certain drugs and compounds, and can be identical or similiar to lichen planus. A 75-year-old woman who had taken antituberculosis medication(INH, ethambutol, rifampin) for 4 months developed pruritic generalized erythematous papular eruptions on the trunk and extremities, alopecia and nail dystropy. Histopathologic findings were hyperkeratosis, hypergranulosis, hyc rophic degenaration of basal layer, band like lymphohistiocytic infiltration in the upper dermis and perivascular lymphohistiocytic infiltration in the deep dermis. She was treated with systemic corticosteroid, and then skin lesion were slightly improved. After termination of antituberculosis medication, skin lesions were markedly improved with residual hyperpigmentation. Alopecia and nail dystrophy were also improved.

Keyword

Lichenoid drug eruption; Autituberculosis drug

MeSH Terms

Aged
Alopecia
Dermis
Drug Eruptions*
Ethambutol
Extremities
Female
Humans
Hyperpigmentation
Lichen Planus
Skin
Ethambutol