Korean J Gynecol Oncol.  2007 Jun;18(2):93-100.

A study of support-therapeutic effect and reducing side effect for high-dose vitamin C use of gynecological cancer patients with chemotherapy

• Jeong MS
• Jeong JY
• Park HE
• Lee CJ
• Oh YL
• Kim WG

Abstract

OBJECTIVE
The high-dose vitamin C is useful in the cancer. Consequently its use should have become how many help even from gynecological cancer patient who is in chemotherapy.
METHODS
The study was performed prospective on 57 patients who is diagnosed initially the gynecological cancer during chemotherapy at Gospel Hospital of Kosin University between January 2005 and October 2006. The study was divided to its use 29 (cervix cancer: 17, ovarian cancer 12) and no high-dose vitamin C use 28 (cervix cancer: 11, ovarian cancer 17). The cervix cancer was treated by FP chemotherapy for all stage and the ovarian cancer was treated by CC chemotherapy for stage 1, CT or PT chemotherapy for advanced stage for 6 times respectively regarding a treatment in tumor marker change aspect and the side effect researched GOG classifications.
RESULTS
It evaluated the nausea and vomiting significantly in ovarian cancer (p<0.05). It evaluated for liver enzyme, Hb, WBC, platelet serum creatinine, sensory, motor nervous system and tumor marker with the high-dose vitamin C group does not have the difference from the control group statistically.
CONCLUSION
The high-dose vitamin C is a possibility of reducing nausea and vomiting in the ovarian cancer chemotherapy without other side effect. The regarding a tumor marker change it was not significantly but when it analyzed a recurrence a survival rate with more patient and follow up in long period, its use of should have become how many help in gynecological cancer treatment.

Keyword

High-dose vitamin C; Gynecological cancer; Chemotherapy

MeSH Terms

Ascorbic Acid*
Blood Platelets
Classification
Creatinine
Drug Therapy*
Follow-Up Studies
Humans
Liver
Nausea
Nervous System
Ovarian Neoplasms
Prospective Studies
Recurrence
Survival Rate
Uterine Cervical Neoplasms
Vitamins*
Vomiting
Ascorbic Acid
Creatinine
Vitamins